Oxy-Alkylation of Allylamines with Unactivated Alkyl Bromides and CO2 via Visible-Light-Driven Palladium Catalysis

被引：111

作者：

Sun, Liang ^{[1
]}

Ye, Jian-Heng ^{[1
]}

Zhou, Wen-Jun ^{[1
,2
]}

Zeng, Xin ^{[1
]}

Yu, Da-Gang ^{[1
]}

机构：

[1] Sichuan Univ, Coll Chem, Minist Educ, Key Lab Green Chem & Technol, Chengdu 610064, Sichuan, Peoples R China

[2] Neijiang Normal Univ, Coll Chem & Chem Engn, Neijiang 641112, Peoples R China

来源：

ORGANIC LETTERS | 2018年 / 20卷 / 10期

基金：

中国国家自然科学基金;

关键词：

C-H BONDS; TRANSITION-METAL-FREE; HECK REACTION; COUPLING REACTIONS; RECENT PROGRESS; CARBON-DIOXIDE; DUAL CATALYSIS; ATOM-TRANSFER; CARBOXYLATION; PHOTOREDOX;

D O I：

10.1021/acs.orglett.8b01079

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A selective oxy-alkylation of allylamines with unactivated alkyl bromides and CO2 via visible-light-driven palladium catalysis is reported. The commercially available Pd(PPh3)(4) is used as the sole catalyst in this three component reaction. A variety of tertiary, secondary, and primary alkyl bromides undergo reactions to generate important 2-oxazolidinones in high yields and selectivity. The mild reaction conditions, easy scalability, and facile derivatization of products provide great potential for application in organic synthesis and pharmaceutical chemistry.

引用

页码：3049 / 3052

页数：4

共 86 条

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Acton Q. A., 2012, Oxazolidinones-Advances in Research and Application: Scholarly Paper

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