Pharmacology of moxonidine:: An I1-imidazoline receptor agonist

被引：36
作者：
Ernsberger, P [1 ]
机构：
[1] Case Western Reserve Univ, Sch Med, Div Hypertens, Dept Nutr, Cleveland, OH 44106 USA
[2] Case Western Reserve Univ, Sch Med, Dept Med Hypertens, Cleveland, OH 44106 USA
[3] Case Western Reserve Univ, Sch Med, Dept Pharmacol & Neurosci, Cleveland, OH 44106 USA
来源：
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY | 2000年 / 35卷
关键词：
imidazoline receptor; moxonidine; radioligand binding; PC12 pheochromocytoma cells; rats;
D O I：
10.1097/00005344-200000004-00005
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The I-1-imidazoline receptor is a novel neurotransmitter receptor found mainly in the brainstem, adrenal medulla and kidney. The actions of moxonidine are described at the level of individual biomolecules, cells, tissues, organs and finally with integrative functions. The receptor functions at the cellular level works through arachidonic acid and phospholipid signaling cascades in neuronal cells with the net result of inhibiting sympathetic premotor neurons.
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页码：S27 / S41
页数：15
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