Direct Current Stimulation Promotes BDNF-Dependent Synaptic Plasticity: Potential Implications for Motor Learning

被引：1020

作者：

Fritsch, Brita ^{[2
,3
]}

Reis, Janine ^{[1
,3
]}

Martinowich, Ken ^{[5
]}

Schambra, Heidi M. ^{[1
]}

Ji, Yuanyuan ^{[4
]}

Cohen, Leonardo G. ^{[1
]}

Lu, Bai ^{[4
,5
]}

机构：

[1] NINDS, Human Cort Physiol & Stroke Neurorehabil Sect, NIH, Bethesda, MD 20892 USA

[2] NINDS, Epilepsy Res Sect, NIH, Bethesda, MD 20892 USA

[3] Univ Freiburg, Dept Neurol, D-79106 Freiburg, Germany

[4] NICHHD, Lab Cellular & Synapt Neurophysiol, Bethesda, MD 20892 USA

[5] NIMH, Gene Cognit & Psychosis Program GCAP, NIH, Bethesda, MD 20892 USA

来源：

NEURON | 2010年 / 66卷 / 02期

关键词：

LONG-TERM POTENTIATION; NONINVASIVE CORTICAL STIMULATION; VAL66MET POLYMORPHISM; NEUROTROPHIC FACTOR; EXCITABILITY SHIFTS; CEREBRAL-CORTEX; MEMORY; MODULATION; MECHANISMS; NEURONS;

D O I：

10.1016/j.neuron.2010.03.035

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Despite its increasing use in experimental and clinical settings, the cellular and molecular mechanisms underlying transcranial direct current stimulation (tDCS) remain unknown. Anodal tDCS applied to the human motor cortex (M1) improves motor skill learning. Here, we demonstrate in mouse M1 slices that DCS induces a long-lasting synaptic potentiation (DCS-LTP), which is polarity specific, NMDA receptor dependent, and requires coupling of DCS with repetitive low-frequency synaptic activation (LFS). Combined DCS and LFS enhance BDNF-secretion and TrkB activation, and DCS-LTP is absent in BDNF and TrkB mutant mice, suggesting that BDNF is a key mediator of this phenomenon. Moreover, the BDNF val66met polymorphism known to partially affect activity-dependent BDNF secretion impairs motor skill acquisition in humans and mice. Motor learning is enhanced by anodal tDCS, as long as activity-dependent BDNF secretion is in place. We propose that tDCS may improve motor skill learning through augmentation of synaptic plasticity that requires BDNF secretion and TrkB activation within M1.

引用

页码：198 / 204

页数：7

共 41 条

[1]

Akaneya Y, 1997, J NEUROSCI, V17, P6707

[2]

Balkowiec A, 2002, J NEUROSCI, V22, P10399

[3] LONG-LASTING CHANGES IN LEVEL OF ELECTRICAL ACTIVITY OF CEREBRAL CORTEX PRODUCED BY POLARIZING CURRENTS [J].