The promise of biomarkers for personalized renal cancer care

被引：14
作者：
Devarajan, Prasad [1 ]
机构：
[1] Univ Cincinnati, Sch Med, Cincinnati Childrens Hosp, Med Ctr, Cincinnati, OH 45229 USA
来源：
KIDNEY INTERNATIONAL | 2010年 / 77卷 / 09期
关键词：
GELATINASE-ASSOCIATED LIPOCALIN; CARDIAC-SURGERY; INJURY;
D O I：
10.1038/ki.2010.26
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Biomarkers hold promise for personalizing renal cancer care by potentially identifying patients most likely to benefit from novel therapies. Porta and colleagues report that among subjects with advanced renal-cell carcinoma receiving sunitinib treatment, those with above-normal levels of the circulating biomarkers vascular endothelial growth factor and neutrophil gelatinase-associated lipocalin displayed significantly lower progression-free survival times. This Commentary reviews the current status of these biomarkers with respect to methodological issues, specificity, and biological plausibility. Kidney International (2010) 77, 755-757. doi: 10.1038/ki.2010.26
引用
收藏
页码：755 / 757
页数：4
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