Tumor-associated macrophages press the angiogenic switch in breast cancer

被引：356
作者：
Lin, Elaine Y.
Pollard, Jeffrey W.
机构：
[1] Albert Einstein Coll Med, Ctr Reprod Biol & Womens Hlth, Dept Dev & Mol Biol, Bronx, NY 10461 USA
[2] Albert Einstein Coll Med, Albert Einstein Canc Ctr, Dept Med, Div Oncol, Bronx, NY 10461 USA
来源：
CANCER RESEARCH | 2007年 / 67卷 / 11期
关键词：
D O I：
10.1158/0008-5472.CAN-07-0912
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The development of a supportive vasculature is essential for tumor progression. In a mouse model of breast cancer, we found that tumor-associated macrophages that are recruited to the tumor just before malignant conversion are essential for the angiogenic switch. These findings establish a causal linkage to explain well-documented clinical correlations between macrophages, microvessel density, and poor prognosis in breast tumors.
引用
收藏
页码：5064 / 5066
页数：3
相关论文
共 17 条
[1]   ADVANCES IN DIAGNOSTIC-IMAGING AND OVERESTIMATIONS OF DISEASE PREVALENCE AND THE BENEFITS OF THERAPY [J].
BLACK, WC ;
WELCH, HG .
NEW ENGLAND JOURNAL OF MEDICINE, 1993, 328 (17) :1237-1243
[2]   Macrophages: Obligate partners for tumor cell migration, invasion, and metastasis [J].
Condeelis, J ;
Pollard, JW .
CELL, 2006, 124 (02) :263-266
[3]  
Crowther M, 2001, J LEUKOCYTE BIOL, V70, P478
[4]   INDUCTION OF ANGIOGENESIS DURING THE TRANSITION FROM HYPERPLASIA TO NEOPLASIA [J].
FOLKMAN, J ;
WATSON, K ;
INGBER, D ;
HANAHAN, D .
NATURE, 1989, 339 (6219) :58-61
[5]   Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis [J].
Hanahan, D ;
Folkman, J .
CELL, 1996, 86 (03) :353-364
[6]   The hallmarks of cancer [J].
Hanahan, D ;
Weinberg, RA .
CELL, 2000, 100 (01) :57-70
[7]   Tumor-associated macrophages in breast cancer [J].
Leek, RD ;
Harris, AL .
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA, 2002, 7 (02) :177-189
[8]  
Leek RD, 1996, CANCER RES, V56, P4625
[9]   Distinct role of macrophages in different tumor microenvironments [J].
Lewis, CE ;
Pollard, JW .
CANCER RESEARCH, 2006, 66 (02) :605-612
[10]   Macrophages regulate the angiogenic switch in a mouse model of breast cancer [J].
Lin, Elaine Y. ;
Li, Jiu-Feng ;
Gnatovskiy, Leoid ;
Deng, Yan ;
Zhu, Liyin ;
Grzesik, Dustin A. ;
Qian, Hong ;
Xue, Xiao-nan ;
Pollard, Jeffrey W. .
CANCER RESEARCH, 2006, 66 (23) :11238-11246
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