Platelet serotonin concentration and depressive symptoms in patients with schizophrenia

被引:27
作者
Peitl, Vjekoslav [1 ,2 ]
Vidrih, Branka [1 ,2 ]
Karlovic, Zoran [1 ]
Getaldic, Biserka [1 ]
Peitl, Milena [1 ]
Karlovic, Dalibor [1 ,2 ]
机构
[1] Univ Hosp Ctr Sestre Milosrdnice, Dept Psychiat, Vinogradska Cesta 29, Zagreb 10000, Croatia
[2] Croatian Catholic Univ, Zagreb, Croatia
关键词
Blood platelets; Serotonin; Schizophrenia; Depression; Psychiatric status rating scales; 5-HT LEVELS; NEGATIVE SYMPTOMS; PREVALENCE; EPISODE; SPECIFICITY; PSYCHOSES; SUICIDE; SCALE;
D O I
10.1016/j.psychres.2016.03.006
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Depressive symptoms seem to be frequent in schizophrenia, but so far they have received less attention than other symptom domains. Impaired serotonergic neurotransmission has been implicated in the pathogenesis of depression and schizophrenia. The objectives of this study were to investigate platelet serotonin concentrations in schizophrenic patients with and without depressive symptoms, and to investigate the association between platelet serotonin concentrations and symptoms of schizophrenia, mostly depressive symptoms. A total of 364 patients were included in the study, 237 of which had significant depressive symptoms. Significant depressive symptoms were defined by the cut-off score of 7 or more on Calgary Depression Rating Scale (CDSS). Platelet serotonin concentrations were assessed by the enzyme-linked immunosorbent assay (ELISA). Prevalence of depression in patients with schizophrenia was 65.1%. Schizophrenic patients with depressive symptoms showed lower platelet serotonin concentrations (mean +/- SD; 490.6 +/- 401.2) compared to schizophrenic patients without depressive symptoms (mean SD; 660.9 +/- 471.5). An inverse correlation was established between platelet serotonin concentration and depressive symptoms, with more severe symptoms being associated with lower platelet serotonin concentrations. Depressive symptoms in schizophrenic patients may be associated with reduced concentrations of platelet serotonin. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:105 / 110
页数:6
相关论文
共 44 条
  • [1] Abi-Dargham A, 1997, J NEUROPSYCH CLIN N, V9, P1
  • [2] SPECIFICITY OF THE CALGARY-DEPRESSION-SCALE FOR SCHIZOPHRENICS
    ADDINGTON, D
    ADDINGTON, J
    MATICKATYNDALE, E
    [J]. SCHIZOPHRENIA RESEARCH, 1994, 11 (03) : 239 - 244
  • [3] [Anonymous], 1985, PLATELETS PHYSL PHAR
  • [4] [Anonymous], 2014, ADHERENCE ANTIPSYCHO
  • [5] Serotonin level and serotonin uptake in human platelets: A variable interrelation under marked physiological influences
    Balija, Melita
    Bordukalo-Niksic, Tatjana
    Mokrovic, Gordana
    Banovic, Miroslav
    Cicin-Sain, Lipa
    Jernej, Branimir
    [J]. CLINICA CHIMICA ACTA, 2011, 412 (3-4) : 299 - 304
  • [6] Depressive symptoms in stable chronic schizophrenia: prevalence and relationship to psychopathology and treatment
    Baynes, D
    Mulholland, C
    Cooper, SJ
    Montgomery, RC
    MacFlynn, G
    Lynch, G
    Kelly, C
    King, DJ
    [J]. SCHIZOPHRENIA RESEARCH, 2000, 45 (1-2) : 47 - 56
  • [7] Prevalence and background factors of depression in first admitted schizophrenic patients
    Bottlender, R
    Strauss, A
    Möller, HJ
    [J]. ACTA PSYCHIATRICA SCANDINAVICA, 2000, 101 (02) : 153 - 160
  • [8] Psychiatric Comorbidities and Schizophrenia
    Buckley, Peter F.
    Miller, Brian J.
    Lehrer, Douglas S.
    Castle, David J.
    [J]. SCHIZOPHRENIA BULLETIN, 2009, 35 (02) : 383 - 402
  • [9] Depression in schizophrenia: prevalence and relationship to quality of life
    Cardoso, Clareci Silva
    Caiaffa, Waleska Teixeira
    Bandeira, Marina
    Siqueira, Arminda Lucia
    da Silva, Jussara Teixeira
    Penido Fonseca, Jose Otavio
    [J]. CADERNOS DE SAUDE PUBLICA, 2007, 23 (09): : 2035 - 2048
  • [10] Depressive symptoms in first episode schizophrenia spectrum disorder
    Cotton, S. M.
    Lambert, M.
    Schimmelmann, B. G.
    Mackinnon, A.
    Gleeson, J. F. M.
    Berk, M.
    Hides, L.
    Chanen, A.
    McGorry, P. D.
    Conus, P.
    [J]. SCHIZOPHRENIA RESEARCH, 2012, 134 (01) : 20 - 26