Effects of myostatin and growth factors on cultured human cells

被引：5

作者：

Shishkin, SS ^{[1
]}

Krokhina, TB

Akhunov, VS

Makarov, AA

Popov, VO

机构：

[1] Russian Acad Sci, Bach Inst Biochem, Moscow 119071, Russia

[2] Russian Acad Med Sci, Med Genet Res Ctr, Moscow 115478, Russia

来源：

APPLIED BIOCHEMISTRY AND MICROBIOLOGY | 2004年 / 40卷 / 06期

基金：

俄罗斯基础研究基金会;

关键词：

D O I：

10.1023/B:ABIM.0000046987.85559.ab

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A dedicated cell-based biological test system was used to study specific effects of myostatin and other human growth factors on the proliferation of cultured myoblasts and fibroblasts. Myostatin inhibited myoblast growth without affecting human fibroblasts. In this test system, human growth hormone and insulin-like growth factor I acted as antagonists of myostatin, which indicates that these agents have a potential for blocking its effects in vivo.

引用

页码：547 / 550

页数：4

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