An efficient and solvent-free one-pot synthesis of dihydropyrimidinones under microwave irradiation

被引：51

作者：

Jiang, Cheng ^{[1
]}

You, Qi Dong ^{[1
]}

机构：

[1] China Pharmaceut Univ, Dept Med Chem, Nanjing 210009, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2007年 / 18卷 / 06期

基金：

高等学校博士学科点专项科研基金;

关键词：

Biginelli reaction; 3,4-dihydropyrimidone; microwave; solvent-free; formic acid;

D O I：

10.1016/j.cclet.2007.04.002

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives using formic acid as catalyst, from aldehydes, beta-ketoester and urea(thiourea) without solvent under the irradiation of microwave is described. Compared with the classical Biginelli reaction, this new method has the advantage of good yields (77-94% for aromatic aldehydes) and short reaction time (3-8 min). (C) 2007 Qi Dong You. Published by Elsevier B.V. on behalf of Chinese hemical Society. All rights reserved.

引用

页码：647 / 650

页数：4

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