Catalyst-free cyclization of anthranils and cyclic amines: one-step synthesis of rutaecarpine

被引：34
作者：
Li, Jian [1 ]
Wang, Zheng-Bing [1 ]
Xu, Yue [1 ]
Lu, Xue-Chen [1 ]
Zhu, Shang-Rong [1 ]
Liu, Li [1 ]
机构：
[1] Changzhou Univ, Sch Pharmaceut Engn & Life Sci, Jiangsu Key Lab Adv Catalyt Mat & Technol, Changzhou 213164, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 80期
基金：
中国国家自然科学基金;
关键词：
LUOTONIN-A; EVODIA-RUTAECARPA; ALKALOIDS; QUINAZOLINE; DERIVATIVES; HETEROCYCLES; ANNULATION; QUINOLINE; ANALOGS; HYBRIDS;
D O I：
10.1039/c9cc06160f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An efficient synthesis of a variety of quinazolinone derivatives via a direct cyclization reaction between commercially available anthranils and cyclic amines is described. The developed transformation proceeds with the merits of high step- and atom-efficiency, a broad substrate scope, and good to excellent yields, without additional catalysts, and offers a practical way for the preparation of rutaecarpine and its derivatives with structural diversity.
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页码：12072 / 12075
页数：4
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