The how's and what's of vaccine reactogenicity

被引：344

作者：

Herve, Caroline ^{[1
]}

Laupeze, Beatrice ^{[1
]}

Del Giudice, Giuseppe ^{[2
]}

Didierlaurent, Arnaud M. ^{[1
]}

Da Silva, Fernanda Tavares ^{[1
]}

机构：

[1] GSK, Wavre, Belgium

[2] GSK, Siena, Italy

来源：

NPJ VACCINES | 2019年 / 4卷 / 1期

关键词：

HEPATITIS-A VACCINE; INFLUENZA VACCINE; IMMUNE-RESPONSES; RUBELLA VACCINES; ADVERSE EVENTS; BRIGHTON COLLABORATION; PSYCHOLOGICAL STRESS; VARICELLA VACCINE; LICENSED VACCINES; MMRV VACCINATION;

D O I：

10.1038/s41541-019-0132-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Reactogenicity represents the physical manifestation of the inflammatory response to vaccination, and can include injection-site pain, redness, swelling or induration at the injection site, as well as systemic symptoms, such as fever, myalgia, or headache. The experience of symptoms following vaccination can lead to needle fear, long-term negative attitudes and non-compliant behaviours, which undermine the public health impact of vaccination. This review presents current knowledge on the potential causes of reactogenicity, and how host characteristics, vaccine administration and composition factors can influence the development and perception of reactogenicity. The intent is to provide an overview of reactogenicity after vaccination to help the vaccine community, including healthcare professionals, in maintaining confidence in vaccines by promoting vaccination, setting expectations for vaccinees about what might occur after vaccination and reducing anxiety by managing the vaccination setting.

引用

页数：11

共 113 条

[31] Effects of prophylactic ibuprofen and paracetamol administration on the immunogenicity and reactogenicity of the 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugated vaccine (PHiD-CV) co-administered with DTPa-combined vaccines in children: An open-label, randomized, controlled, non-inferiority trial [J].