A noninvasive dose estimation system for clinical BNCT based on PG-SPECT - Conceptual study and fundamental experiments using HPGe and CdTe semiconductor detectors

A noninvasive method for measuring the absorbed dose distribution during the administration of clinical boron neutron capture therapy (BNCT) using an online three-dimensional (3D) imaging system is presented. This system is designed to provide more accurate information for treatment planning and dosimetry. The single-photon emission computed tomography (SPECT) technique is combined with prompt gamma-ray analysis (PGA) to provide an ideal dose estimation system for BNCT. This system is termed PC-SPECT. The fundamental feasibility of the PC-SPECT system for BNCT is confirmed under the following conditions: (1) a voxel size of 1x1x1 cm(3), comparable to the spatial resolution of our standard dosimetric technique using gold wire activation, where data are available for every 5-10 mm of wire length; (2) a reaction rate of (10)B(n,alpha)(7)Li within the measurement volume is greater than 1.1x10(6) interactions/cm(3)/s, corresponding to a thermal neutron flux of 5 x 10(8) n/cm(2)/s and a (10)B concentration of greater than 10 ppm For the deepest part of the tumor volume under typical BNCT clinical conditions; (3) statistical uncertainty of the count rate for (10)B(n, alpha)(7)Li prompt gamma rays is 10% or less. The desirable characteristics of a detector for the PG-SPECT system were determined by basic experiments using both HPGe and CdTe semiconductor detectors. The CdTe semiconductor detector has the greatest potential fur this system because of its compactness and simplicity of maintenance. (C) 2000 American Association of Physicists in Medicine. [S0094-2405(00)00509-5].