Post-PKS tailoring steps in natural product-producing actinomycetes from the perspective of combinatorial biosynthesis

被引：120

作者：

Olano, Carlos ^{[1
]}

Mendez, Carmen ^{[1
]}

Salas, Jose A. ^{[1
]}

机构：

[1] Univ Oviedo, Dept Biol Func, IUOPA, E-33006 Oviedo, Spain

来源：

NATURAL PRODUCT REPORTS | 2010年 / 27卷 / 04期

关键词：

STREPTOMYCES-COELICOLOR A3(2); ANTITUMOR ANTIBIOTIC C-1027; AMYCOLATOPSIS-MEDITERRANEI S699; MODULAR POLYKETIDE SYNTHASES; TARGETED GENE DISRUPTION; X-RAY-DIFFRACTION; ANGIOGENESIS INHIBITOR BORRELIDIN; VILLIGER MONOOXYGENASE MTMOIV; ERYTHROMYCIN C-12 HYDROXYLASE; 2 GLYCOSYLTRANSFERASE GENES;

D O I：

10.1039/b911956f

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In recent years, a number of gene clusters involved in the biosynthesis of polyketide compounds have been characterized and the genes have been used for designing and developing novel chemical entities by combinatorial biosynthesis. This review covers the highlights of combinatorial biosynthesis using polyketide-modifying enzymes such as oxidoreductases, group transferases, halogenases, cyclases and deoxysugar biosynthesis enzymes, focusing on those from actinomycetes (with 315 references cited).

引用

页码：571 / 616

页数：46

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