Structural diversity and bioactivity of labdane and clerodane diterpenoids

被引：1
作者：
Ohsaki, A [1 ]
机构：
[1] Tokyo Med & Dent Univ, Inst Biomat & Bioengn, Chiyoda Ku, Tokyo 1010062, Japan
来源：
JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN | 2004年 / 62卷 / 09期
关键词：
labdane; clerodane; diterpenoid; rearranged diterpenoid; natural products; secondary metabolites; bioactive compounds; biosynthesis;
D O I：
10.5059/yukigoseikyokaishi.62.872
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
More than a thousand compounds possessing labdane and clerodane-type skeletons have been isolated from the natural sources, such as plants, marine products, fungi, and bacteria. These diterpenoids form big groups in secondary metabolites. Biogenetically, both the labdane and clerodane skeletons are derived from geranyl geranylpyrophosphate. However, their biological roles are not well known. This review describes current issues in research on labdane and clerodane-type diterpenoids, including the rearranged skeletons, related to their structural diversity and bioactivities. Synthetic challenges relevant to labdane and clerodane-type diterpenoids, an example of an enantiomeric labdane-type diterpene, and a recent genomic study of the biosynthesis of diterpenoids are also described.
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收藏
页码：872 / 881
页数：10
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