Minor metabolites from the ascidian Stolonica socialis and cytotoxicity of stolonoxides

被引：15

作者：

Durán, R ^{[1
]}

Zubía, E ^{[1
]}

Ortega, MJ ^{[1
]}

Naranjo, S ^{[1
]}

Salvá, J ^{[1
]}

机构：

[1] Fac Ciencias Mar, Dept Quim Organ, Cadiz 11510, Spain

来源：

TETRAHEDRON | 2000年 / 56卷 / 33期

关键词：

marine metabolites; biologically active compounds; peroxides;

D O I：

10.1016/S0040-4020(00)00554-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Bioassay guided isolation of the metabolites of the ascidian Stolonica socialis from Tarifa Island (Cadiz, Spain) led to a series of cyclic peroxides. A 9:1 mixture of stolonoxide A and the new stolonoxide B, a 6:4 mixture of their corresponding sodium salts, and a minor 6:4 mixture of the new stolonoxides C and D obtained as their sodium salts. Their structures were established by spectroscopic study of both the natural mixtures, whose constituents differ in the geometry of a double bond, and the corresponding methyl esters. The strong cytotoxicity exhibited by the stolonoxides against five tumor cell lines is presented and discussed. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：6031 / 6037

页数：7

共 7 条

[1] THE RELATIVE CONFIGURATION OF ACETOGENINS ISOLATED FROM ANNONA-SQUAMOSA - ANNONIN-I (SQUAMOCIN) AND ANNONIN-VI [J].