Medicinal Chemistry of Incretin Mimetics and DPP-4 Inhibitors

被引：37
|
作者：
Zettl, Heiko [1 ]
Schubert-Zsilavecz, Manfred [1 ]
Steinhilber, Dieter [1 ]
机构：
[1] Goethe Univ Frankfurt, Inst Pharmaceut Chem, D-60438 Frankfurt, Germany
来源：
CHEMMEDCHEM | 2010年 / 5卷 / 02期
关键词：
DPP-4; inhibitors; drug discovery; incretin mimetics; medicinal chemistry; DIPEPTIDYL-PEPTIDASE-IV; GLUCAGON-LIKE PEPTIDE-1; TYPE-2; DIABETES-MELLITUS; ANTIHYPERGLYCEMIC PROPERTIES; HEALTHY-VOLUNTEERS; RECEPTOR AGONISTS; CRYSTAL-STRUCTURE; POTENT; PHARMACOKINETICS; PHARMACODYNAMICS;
D O I：
10.1002/cmdc.200900448
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
引用
收藏
页码：179 / 185
页数：7
相关论文
共 50 条
  • [11] Recent approaches to medicinal chemistry and therapeutic potential of dipeptidyl peptidase-4 (DPP-4) inhibitors
    Patel, Bhumika D.
    Ghate, Manjunath D.
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 74 : 574 - 605
  • [12] Insight into Structure Activity Relationship of DPP-4 Inhibitors for Development of Antidiabetic Agents
    Mathur, Vishal
    Alam, Ozair
    Siddiqui, Nadeem
    Jha, Mukund
    Manaithiya, Ajay
    Bawa, Sandhya
    Sharma, Naveen
    Alshehri, Sultan
    Alam, Prawez
    Shakeel, Faiyaz
    MOLECULES, 2023, 28 (15):
  • [13] Novel DPP-4 inhibitors against diabetes
    Liu, Yang
    Hu, Yongzhou
    FUTURE MEDICINAL CHEMISTRY, 2014, 6 (07) : 793 - 808
  • [14] How Effective are Gliflozins as DPP-4 Inhibitors? A Computational Study
    Saini, Kunika
    Khan, Yousuf
    Sharma, Smriti
    THEORETICAL FOUNDATIONS OF CHEMICAL ENGINEERING, 2023, 57 (03) : 403 - 410
  • [15] Incretin mimetics (GLP-1 receptor agonists) and incretin enhancers (DPP-4 inhibitors): New antidiabetic medications based on physiologic insulinotropic gut hormones
    M.A. Nauck
    Der Diabetologe, 2007, 3 (5): : 387 - 398
  • [16] DPP-4 inhibitors and atherosclerosis: The promise
    Jialal, Ishwarlal
    Bajaj, Mandeep
    ATHEROSCLEROSIS, 2013, 227 (02) : 224 - 225
  • [17] Renoprotective Effects of DPP-4 Inhibitors
    Kawanami, Daiji
    Takashi, Yuichi
    Takahashi, Hiroyuki
    Motonaga, Ryoko
    Tanabe, Makito
    ANTIOXIDANTS, 2021, 10 (02) : 1 - 17
  • [18] DPP-4 inhibitors: focus on safety
    Tella, Sri Harsha
    Rendell, Marc S.
    EXPERT OPINION ON DRUG SAFETY, 2015, 14 (01) : 127 - 140
  • [19] Cardiovascular safety and DPP-4 inhibitors
    Carty, David M.
    Drummond, Russell
    Fisher, Miles
    PRACTICAL DIABETES, 2013, 30 (02) : 78 - 81
  • [20] In Silico Study of Flavonoids as DPP-4 and α-glucosidase Inhibitors
    Kaur, Jasmin
    Singla, Ramit
    Jaitak, Vikas
    LETTERS IN DRUG DESIGN & DISCOVERY, 2018, 15 (06) : 634 - 642
12345