Gallium-modified chitosan/poly(acrylic acid) bilayer coatings for improved titanium implant performances

被引：50
作者：
Bonifacio, Maria A. [1 ]
Cometa, Stefania [2 ]
Dicarlo, Manuela [3 ]
Baruzzi, Federico [4 ]
de Candia, Silvia [4 ]
Gloria, Antonio [5 ]
Giangregorio, Maria M. [6 ]
Mattioli-Belmonte, Monica [3 ]
De Giglio, Elvira [1 ]
机构：
[1] Univ Bari Aldo Moro, Dept Chem, Bari, Italy
[2] Jaber Innovat Srl, Rome, Italy
[3] Univ Politecn Marche, Dept Clin & Mol Sci, Ancona, Italy
[4] Natl Res Council Italy, Inst Sci Food Prod, ISPA CNR, Bari, Italy
[5] Natl Res Council Italy, Inst Polymers Composites & Biomat, IPCB CNR, Naples, Italy
[6] Natl Res Council Italy, Inst Nanotechnol, NANOTEC CNR, Bari, Italy
来源：
CARBOHYDRATE POLYMERS | 2017年 / 166卷
关键词：
Chitosan-based bilayer; Gallium; Titanium; Antibacterial agents; Electrochemical deposition; Biocompatibility; PSEUDOMONAS-AERUGINOSA; BIOCOMPATIBILITY; NANOPARTICLES; COMPLEXATION; CHITOSAN; CELLS;
D O I：
10.1016/j.carbpol.2017.03.009
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A gallium-modified chitosan/poly(acrylic acid) bilayer was obtained by electrochemical techniques on titanium to reduce orthopaedic and/or dental implants failure. The bilayer in vitro antibacterial properties and biocompatibility were evaluated against Escherichia coli and Pseudomonas aeruginosa and on MG63 osteoblast-like cells, respectively. Gallium loading into the bilayer was carefully tuned by the electrochemical deposition time to ensure the best balance between antibacterial activity and cytocompatibility. The 30 min deposition time was able to reduce in vitro the viable cell counts of E. coli and P. aeruginosa of 2 and 3 log cfu/sheet, respectively. Our results evidenced that the developed antibacterial coating did not considerably alter the mechanical flexural properties of titanium substrates and, in addition, influenced positively MG63 adhesion and proliferation. Therefore, the gallium-modified chitosan/poly(acrylic acid) bilayer can be exploited as a promising titanium coating to limit bacterial adhesion and proliferation, while maintaining osseointegrative potential. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：348 / 357
页数：10
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