The evolution of T-cell depletion in haploidentical stem-cell transplantation

被引：52

作者：

Or-Geva, Noga ^{[1
]}

Reisner, Yair ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Immunol, 234 Herzl St, IL-7600 Rehovot, Israel

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2016年 / 172卷 / 05期

关键词：

graft-versus host disease; nonmyeloablative; reduced conditioning; anti-third-party CD8(+) Tcm; veto cell; graft anti-tumour; VERSUS-HOST-DISEASE; BONE-MARROW-TRANSPLANTATION; SEVERE COMBINED IMMUNODEFICIENCY; MONOCLONAL-ANTIBODY OKT3; ACUTE-LEUKEMIA; HEMATOLOGIC MALIGNANCIES; ADOPTIVE IMMUNOTHERAPY; PROGENITOR CELLS; FREE SURVIVAL; LONG-TERM;

D O I：

10.1111/bjh.13868

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

T-cell depletion (TCD) can prevent the onset of graft-versus-host disease (GvHD) in animal models of bone marrow transplantation; this manipulation enabled the successful application in the 1980s of T-cell depleted bone marrow (BM) for the treatment of babies with severe combined immune deficiency (SCID). However, in leukaemia patients, implementation of T-cell depletion has been more difficult, especially due to high rate of graft-rejection, leukaemia relapse and delayed immune reconstitution. These hurdles were gradually overcome by modifying the cell composition of the graft, and by reducing the toxicities associated with conditioning protocols. Although no gold standard' TCD method exists, T-cell depletion in its modern forms could offer clinical benefit, even for patients with a matched sibling donor.

引用

页码：667 / 684

页数：18

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