Properties of hydrogels of atactic poly(vinyl alcohol)/NaCl/H2O system and their application to drug release

In order to prepare cost-effective physically cross-linked hydrogels including food salt sodium chloride, samples, were prepared with various concentrations of NaCl and respective atactic poly(vinyl alcohol) (a-PVA), and were evaluated. It had been observed that hydrogels containing NaCl concentration (9-11 wt%) along with a-PVA concentration 9-5% respectively exhibited higher melting points (91.5-95.1degreesC). A higher melting point characterizes the hydrogel composition of a system like a-PVA(7%)/NaCl(11%)/H2O. The swelling degree of this hydrogel was found to be comparatively better at 37degreesC than at any other temperature studied here. However, irregular Fickian swelling was found at this temperature. The UV light absorption maximum at 362-364 nm and minimum at 351 urn for this hydrogel had been found as evidence of physical cross-linking. A drug, theophylline was loaded by solvent-sorption and feed-mixture dissolving methods. The feed-mixture dissolving method is better than solvent sorption because of high drug loading, comparatively low fraction release rate and more sustained-release of drug than that of solvent-sorption. Theophylline was released twice as fast from the hydrogel after solvent-sorption drug loading (3h) than from that which used the feed-mixture dissolving method (6.5h). Theophylline-loaded hydrogels of this system (feed-mixture dissolving) were then prepared at high temperature (60degreesC) thawing for 6h followed by chilling at 0.4degreesC for 3h as one cycle. And the drug release behaviour and mass transfer were found almost the same as for chilling (24h at 0.4degreesC)-thawing (48h at room temperature). Drug release behaviour was studied as apparently irregular Fickian diffusion (Higuchi Matrix Dissolution Model). (C) 2002 Society of Chemical Industry.