Fibroblast growth factor 20 (FGF20) gene polymorphism and risk of Parkinson's disease: a meta-analysis

被引：10
作者：
Zhu, Ruixia [1 ]
Zhu, Ying [1 ]
Liu, Xu [1 ]
He, Zhiyi [1 ]
机构：
[1] China Med Univ, Affiliated Hosp 1, Shenyang 110001, Peoples R China
来源：
NEUROLOGICAL SCIENCES | 2014年 / 35卷 / 12期
基金：
中国国家自然科学基金;
关键词：
Parkinson's disease; Meta-analysis; FGF-20; Gene variant; ALPHA-SYNUCLEIN; DOPAMINERGIC-NEURONS; ASSOCIATION; POPULATION; CHINESE; FGF-20;
D O I：
10.1007/s10072-014-1853-y
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Fibroblast growth factor 20 (FGF20) widely expressed in the substantia nigra is a neurotrophic factor and enhances the survival of midbrain dopaminergic neurons. Genetic association between variants in FGF20 gene (rs1721100) and PD has been reported, however, the results have been conflicting. A total of 3,463 PD patients and 4,606 controls from 5 case-control studies, which were identified by searching Web of Science, Embase and PubMed database up to March 2014, were collected for this meta-analysis. The meta-analysis showed an association between FGF20 gene rs1721100 polymorphism and risk of Parkinson's disease under a recessive model (GG versus CG+GG; OR = 1.15, 95 % CI 1.02-1.29, p = 0.02) but not under a dominant model (CG+GG versus CC; OR = 1.03, 95 % CI 0.93-1.13, p = 0.57). These findings suggest that rs1721100 GG genotype within FGF20 gene is a risk factor for PD. To our knowledge, this is the first meta-analysis to access to the association of FGF20 gene rs1721100 polymorphism with PD risk.
引用
收藏
页码：1889 / 1894
页数：6
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