Fibroblasts form a hospitable metastatic niche in the liver

被引：7

作者：

Erez, Neta ^{[1
]}

机构：

[1] Tel Aviv Univ, Sackler Sch Med, Dept Pathol, IL-69978 Tel Aviv, Israel

来源：

NATURE CELL BIOLOGY | 2016年 / 18卷 / 05期

关键词：

PANCREATIC DUCTAL ADENOCARCINOMA; CANCER-ASSOCIATED FIBROBLASTS;

D O I：

10.1038/ncb3352

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The liver is the most common metastatic route of pancreatic cancer. Early recruitment of granulin-secreting inflammatory monocytes to the liver is now shown to reprogram hepatic stellate cells into myofibroblasts that modulate the liver microenvironment to support the growth of metastasizing tumour cells.

引用

页码：465 / 466

页数：3

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