Comparison of Sirolimus-Eluting Stenting With Minimally Invasive Bypass Surgery for Stenosis of the Left Anterior Descending Coronary Artery

被引：60

作者：

Blazek, Stephan ^{[1
]}

Rossbach, Cornelius ^{[1
]}

Borger, Michael A. ^{[2
]}

Fuernau, Georg ^{[1
]}

Desch, Steffen ^{[1
,3
]}

Eitel, Ingo ^{[1
,3
]}

Stiermaier, Thomas ^{[1
]}

Lurz, Philipp ^{[1
]}

Holzhey, David ^{[2
]}

Schuler, Gerhard ^{[1
]}

Mohr, Friedrich-Wilhelm ^{[2
]}

Thiele, Holger ^{[1
,3
]}

机构：

[1] Univ Leipzig, Ctr Heart, Dept Internal Med Cardiol, D-04109 Leipzig, Germany

[2] Univ Leipzig, Ctr Heart, Dept Cardiac Surg, D-04109 Leipzig, Germany

[3] Univ Lubeck, Med Clin 2, Lubeck, Germany

来源：

JACC-CARDIOVASCULAR INTERVENTIONS | 2015年 / 8卷 / 01期

关键词：

Bypass surgery; Drug-eluting stent; Left anterior descending artery; Long-term follow-up; Percutaneous coronary intervention;

D O I：

10.1016/j.jcin.2014.08.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVES: The aim of this analysis was to assess the 7-year long-term safety and effectiveness of a randomized comparison of percutaneous coronary intervention (PCI) with sirolimus-eluting stents (SES) versus minimally invasive direct coronary artery bypass (MIDCAB) surgery for the treatment of isolated proximal left anterior descending lesions. BACKGROUND: Long-term follow-up data comparing PCI by SES and MIDCAB surgery for isolated proximal left anterior descending lesions are sparse. METHODS: Patients were randomized either to PCI with SES (n = 65) or MIDCAB (n = 65). Follow-up data were obtained after 7 years with respect to the primary composite endpoint of death, myocardial infarction, and target vessel revascularization. Angina was assessed by the Canadian Cardiovascular Society classification and quality of life with Short Form 36 and MacNew quality of life questionnaires. RESULTS: Follow-up was conducted in 129 patients at a median time of 7.3 years (interquartile range: 5.7, 8.3). There were no significant differences in the incidence of the primary composite endpoint between groups (22% PCI vs. 12% MIDCAB; p = 0.17) or the endpoints death (14% vs. 17%; p = 0.81) and myocardial infarction (6% vs. 9%, p = 0.74). However, the target vessel revascularization rate was higher in the PCI group (20% vs. 1.5%; p < 0.001). Clinical symptoms and quality of life improved significantly from baseline with both interventions and were similar in magnitude between groups. CONCLUSIONS: At 7-year follow-up, PCI by SES and MIDCAB in isolated proximal left anterior descending lesions yielded similar long-term outcomes regarding the primary composite clinical endpoint and quality of life. Target vessel revascularization was more frequent in the PCI group. © 2015 by the American College of Cardiology Foundation.

引用

页码：30 / 30

页数：1

共 28 条

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