Aspidsaponins E-H, Four new steroidal saponins from the rhizomes of Aspidistra elatior Blume and their anti-inflammatory activity

被引：4

作者：

Sun, Zhi-Ying ^{[1
]}

Zuo, Sheng-Qi ^{[1
]}

Yang, Xia ^{[1
]}

Lan, Jia-Hui ^{[1
]}

Liu, Cheng-Xiong ^{[1
]}

Guo, Zhi-Yong ^{[1
]}

Cheng, Fan ^{[1
]}

Zou, Kun ^{[1
]}

机构：

[1] China Three Gorges Univ, Coll Biol & Pharmaceut Sci, Hubei Key Lab Nat Prod Res & Dev, Yichang 443002, Peoples R China

来源：

PHYTOCHEMISTRY LETTERS | 2019年 / 34卷

关键词：

Aspidistra elatior blume; Steroidal glycosides; NMR; Structural elucidation; Anti-inflammatory activity; INFLAMMATORY RESPONSES; FUROSTANOL SAPONINS; GLYCOSIDES; PI3K/AKT; PATHWAY; CELLS;

D O I：

10.1016/j.phytol.2019.09.014

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Four new furostanol saponins, named aspidsaponins E-H (1-4) were isolated from the rhizomes of Aspidistra elatior Blume. Their structures were determined based on chemical methods and spectral data. Compounds 1 and 2 were a pair of diastereoisomeric furostanol saponins and possessed the highly oxidized structural feature of 1 beta, 2 beta, 3 beta, 4 beta, 5 beta, 26-hexanol-steroids, and compounds 3-4 were steroidal glycosides with a tetra-saccharide chain at C3. The isolated compounds (1-4) were tested in vitro for inhibitory activities against LPS-induced nitric oxide production in RAW264.7 macrophages. Among them, compounds 3 and 4 showed excellent anti-inflammatory activities with IC50 values 82.1 and 65.9 mu M, respectively.

引用

页码：68 / 73

页数：6

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