Pharmacogenomics of ABC transporters and its role in cancer chemotherapy

被引：195
作者：
Sparreboom, A
Danesi, R
Ando, Y
Chan, J
Figg, WD
机构：
[1] NCI, Clin Pharmacol Res Core, Canc Res Ctr, Bethesda, MD 20892 USA
[2] Univ Pisa, Div Pharmacol & Chemotherapy, Dept Oncol, I-56126 Pisa, Italy
来源：
DRUG RESISTANCE UPDATES | 2003年 / 6卷 / 02期
关键词：
pharmacogenetics; polymorphisms; ABC transporters; chemotherapy;
D O I：
10.1016/S1368-7646(03)00005-0
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
ATP-binding cassette (ABC) genes play a role in the resistance of malignant cells to anticancer agents. The ABC gene products, including ABCB1 (P-glycoprotein), ABCC1 (MRP1), ABCC2 (MRP2, cMOAT), and ABCG2 (BCRP, MXR, ABCP) are also known to influence oral absorption and disposition of a wide variety of drugs. As a result, the expression levels of these proteins in humans have important consequences for an individual's susceptibility to certain drug-induced side effects, interactions, and treatment efficacy. Naturally occurring variants in ABC transporter genes have been identified that might affect the function and expression of the protein. This review focuses on recent advances in the pharmacogenomics of ABC transporters, and discusses potential implications of genetic variants for the chemotherapeutic treatment of cancer. Published by Elsevier Science Ltd.
引用
收藏
页码：71 / 84
页数：14
相关论文
共 136 条
  • [41] The influence of MDR1 polymorphisms on P-glycoprotein expression and function in humans
    Fromm, MF
    [J]. ADVANCED DRUG DELIVERY REVIEWS, 2002, 54 (10) : 1295 - 1310
  • [42] Evaluation of accelerator mass spectrometry in a human mass balance and pharmacokinetic study-experience with 14C-labeled (R)-6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone (R115777), a farnesyl transferase inhibitor
    Garner, RC
    Goris, I
    Laenen, AAE
    Vanhoutte, E
    Meuldermans, W
    Gregory, S
    Garner, JV
    Leong, D
    Whattam, M
    Calam, A
    Snel, CAW
    [J]. DRUG METABOLISM AND DISPOSITION, 2002, 30 (07) : 823 - 830
  • [43] MDR1 genotypes do not influence the absorption of a single oral dose of 1 mg digoxin in healthy white males
    Gerloff, T
    Schaefer, M
    Johne, A
    Oselin, K
    Meisel, C
    Cascorbi, I
    Roots, I
    [J]. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2002, 54 (06) : 610 - 616
  • [44] Explaining interindividual variability of docetaxel pharmacokinetics and pharmacodynamics in Asians through phenotyping and genotyping strategies
    Goh, BC
    Lee, SC
    Wang, LZ
    Fan, L
    Guo, JY
    Lamba, J
    Schuetz, E
    Lim, R
    Lim, HL
    Ong, AB
    Lee, HS
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2002, 20 (17) : 3683 - 3690
  • [45] C3435T polymorphism in the MDR1 gene affects the enterocyte expression level of CYP3A4 rather than Pgp in recipients of living-donor liver transplantation
    Goto, M
    Masuda, S
    Saito, H
    Uemoto, S
    Kiuchi, T
    Tanaka, K
    Inui, K
    [J]. PHARMACOGENETICS, 2002, 12 (06): : 451 - 457
  • [46] Multidrug resistance in cancer: Role of ATP-dependent transporters
    Gottesman, MM
    Fojo, T
    Bates, SE
    [J]. NATURE REVIEWS CANCER, 2002, 2 (01) : 48 - 58
  • [47] The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin
    Greiner, B
    Eichelbaum, M
    Fritz, P
    Kreichgauer, HP
    Von Richter, O
    Zundler, J
    Kroemer, HK
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1999, 104 (02) : 147 - 153
  • [48] Hanash SM, 2001, CURR OPIN MOL THER, V3, P538
  • [49] The C3435T mutation in the human MDR1 gene is associated with altered efflux of the P-glycoprotein substrate rhodamine 123 from CD56+ natural killer cells
    Hitzl, M
    Drescher, S
    van der Kuip, H
    Schäffeler, E
    Fischer, J
    Schwab, M
    Eichelbaum, M
    Fromm, MF
    [J]. PHARMACOGENETICS, 2001, 11 (04): : 293 - 298
  • [50] Functional polymorphisms of the human multidrug-resistance gene:: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo
    Hoffmeyer, S
    Burk, O
    von Richter, O
    Arnold, HP
    Brockmöller, J
    Johne, A
    Cascorbi, I
    Gerloff, T
    Roots, I
    Eichelbaum, M
    Brinkmann, U
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (07) : 3473 - 3478
12345678910