Pharmacogenomics of ABC transporters and its role in cancer chemotherapy

被引：195
作者：
Sparreboom, A
Danesi, R
Ando, Y
Chan, J
Figg, WD
机构：
[1] NCI, Clin Pharmacol Res Core, Canc Res Ctr, Bethesda, MD 20892 USA
[2] Univ Pisa, Div Pharmacol & Chemotherapy, Dept Oncol, I-56126 Pisa, Italy
来源：
DRUG RESISTANCE UPDATES | 2003年 / 6卷 / 02期
关键词：
pharmacogenetics; polymorphisms; ABC transporters; chemotherapy;
D O I：
10.1016/S1368-7646(03)00005-0
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
ATP-binding cassette (ABC) genes play a role in the resistance of malignant cells to anticancer agents. The ABC gene products, including ABCB1 (P-glycoprotein), ABCC1 (MRP1), ABCC2 (MRP2, cMOAT), and ABCG2 (BCRP, MXR, ABCP) are also known to influence oral absorption and disposition of a wide variety of drugs. As a result, the expression levels of these proteins in humans have important consequences for an individual's susceptibility to certain drug-induced side effects, interactions, and treatment efficacy. Naturally occurring variants in ABC transporter genes have been identified that might affect the function and expression of the protein. This review focuses on recent advances in the pharmacogenomics of ABC transporters, and discusses potential implications of genetic variants for the chemotherapeutic treatment of cancer. Published by Elsevier Science Ltd.
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收藏
页码：71 / 84
页数：14
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