First Report of Klebsiella oxytoca Strain Simultaneously Producing NDM-1, IMP-4, and KPC-2 Carbapenemases

被引：0
作者：
Wang, Juan [1 ,5 ]
Yuan, Min [2 ]
Chen, Hai [3 ]
Chen, Xia [2 ]
Jia, Yuanchun [2 ]
Zhu, Xiong [3 ]
Bai, Li [4 ]
Bai, Xue [1 ]
Fanning, Seamus [4 ,5 ,6 ]
Lu, Jinxing [2 ]
Li, Juan [2 ]
机构：
[1] Northwest A&F Univ, Coll Vet Med, Yangling, Shaanxi, Peoples R China
[2] Chinese Ctr Dis Control & Prevent, Natl Inst Communicable Dis Control & Prevent, State Key Lab Infect Dis Prevent & Control, Collaborat Innovat Ctr Diag & Treatment Infect Di, Beijing, Peoples R China
[3] Peoples Hosp Sanya, Sanya, Hainan, Peoples R China
[4] Minist Hlth, China Natl Ctr Food Safety Risk Assessment, Key Lab Food Safety Risk Assessment, Beijing, Peoples R China
[5] Univ Coll Dublin, UCD Ctr Food Safety, Sch Publ Hlth Physiotherapy & Sports Sci, Dublin, Ireland
[6] Queens Univ Belfast, Inst Global Food Secur, Sch Biol Sci, Belfast, Antrim, North Ireland
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2017年 / 61卷 / 09期
基金：
中国博士后科学基金; 中国国家自然科学基金;
关键词：
carbapenemases; MDR Klebsiella oxytoca; plasmids; MBLs; KPC-2; ESCHERICHIA-COLI; INCN PLASMID; ENTEROBACTERIACEAE; RESISTANCE; WORLDWIDE; SEQUENCE; ANIMALS; HUMANS; SPREAD; GENES;
D O I：
10.1128/AAC.00877-17
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The nucleotide sequences of five plasmids from one Klebsiella oxytoca isolate were determined using the PacBio RS II system. Plasmid analysis revealed that bla(NDM-1) was carried on an IncX3 plasmid. The bla(IMP-4) and bla(KPC-2) genes were located on IncN and IncP-6 plasmids, respectively. Comparative sequence analysis highlighted the successful spread of carbapenemase-harboring plasmids among different enterobacterial species. We report for the first time, to our knowledge, coproducing NDM-1, KPC-2, and IMP-4 carbapenemases on a K. oxytoca isolate.
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页数：5
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