Nuclear microenvironments in biological control and cancer

被引：125

作者：

Zaidi, Sayyed K.

Young, Daniel W.

Javed, Amjad

Pratap, Jitesh

Montecino, Martin

van Wijnen, Andre

Lian, Jane B.

Stein, Janet L.

Stein, Gary S. ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Worcester, MA 01605 USA

[2] UMASS Mem Canc Ctr, Worcester, MA 01605 USA

[3] Univ Alabama Birmingham, Sch Dent, Inst Oral Hlth Res, Birmingham, AL USA

[4] Univ Concepcion, Fac Ciencias Biol, Dept Bioquim & Biol Mol, Concepcion, Chile

来源：

NATURE REVIEWS CANCER | 2007年 / 7卷 / 06期

关键词：

D O I：

10.1038/nrc2149

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Nucleic acids and regulatory proteins are compartmentalized in microenvironments within the nucleus. This subnuclear organization may support convergence and the integration of physiological signals for the combinatorial control of gene expression, DNA replication and repair. Nuclear organization is modified in many cancers. There are cancer-related changes in the composition, organization and assembly of regulatory complexes at intranuclear sites. Mechanistic insights into the temporal and spatial organization of machinery for gene expression within the nucleus, which is compromised in tumours, provide a novel platform for diagnosis and therapy.

引用

收藏

页码：454 / 463

页数：10

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