Recent advances in stimuli-responsive theranostic systems with aggregation-induced emission characteristics

被引：113

作者：

Hu, Jing-Jing ^{[1
]}

Jiang, Wenlian ^{[1
]}

Yuan, Lizhen ^{[1
]}

Duan, Chong ^{[1
]}

Yuan, Qiming ^{[1
]}

Long, Zi ^{[1
]}

Lou, Xiaoding ^{[1
]}

Xia, Fan ^{[1
]}

机构：

[1] China Univ Geosci, Fac Mat Sci & Chem, Engn Res Ctr Nanogeomat, Minist Educ, Wuhan 430074, Peoples R China

来源：

AGGREGATE | 2021年 / 2卷 / 01期

基金：

中国国家自然科学基金;

关键词：

aggregation induced emission; imaging; stimuli-responsive; theranostics; tumor therapy; FLUORESCENT ORGANIC NANOPARTICLES; MESOPOROUS SILICA NANOPARTICLES; TARGETED PHOTODYNAMIC THERAPY; DEMAND DRUG-RELEASE; INTRACELLULAR DRUG; CANCER-THERAPY; AIE CHARACTERISTICS; MATRIX METALLOPROTEINASES; PLATINUM(IV) PRODRUG; NANO-GRAPHENE;

D O I：

10.1002/agt2.10

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Theranostic systems by integrating the tumor imaging and tumor therapeutic capabilities into one platform have attracted numerous attentions from worldwide researchers. Despite the great developments, their clinical application is still in the nascent stage, owing to the unsatisfied imaging quality and limited therapeutic efficacy. Fortunately, the emerging of aggregation-induced emission (AIE) molecules with unique fluorescence property offers an opportunity to solve the imaging problem. Besides, further utilizing the tumor microenvironments and external triggers to design the stimuli-responsive imaging-guided therapy could enhance the therapeutic efficacy and reduce the side effects. In this review, the advancements in stimuli-responsive theranostic systems with AIE characteristics are summarized. Theranostic systems are first classified according to their treatment modes, and then subdivided based on various stimuli, including pH, redox, enzyme, and light. In each section, the design strategies and application examples are introduced. At last, the current state of the art, limitations, as well as prospects are also discussed.

引用

页码：48 / 65

页数：18

共 137 条

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