Computer-aided Design Techniques for Flow-based Microfluidic Lab-on-a-chip Systems

被引:34
作者
Huang, Xing [1 ]
Ho, Tsung-Yi [2 ]
Guo, Wenzhong [3 ]
Li, Bing [1 ]
Chakrabarty, Krishnendu [4 ]
Schlichtmann, Ulf [1 ]
机构
[1] Tech Univ Munich, Chair Elect Design Automat, D-80333 Munich, Germany
[2] Natl Tsing Hua Univ, Dept Comp Sci, Hsinchu 30013, Taiwan
[3] Fuzhou Univ, Coll Math & Comp Sci, Fuzhou 350116, Peoples R China
[4] Duke Univ, Dept Elect & Comp Engn, Durham, NC 27708 USA
基金
中国国家自然科学基金; 美国国家科学基金会;
关键词
Flow-based microfluidic biochips; computer-aided design; lab-on-a-chip systems; design automation; biochemical applications; CROSS-CONTAMINATION REMOVAL; LARGE-SCALE INTEGRATION; WASH OPTIMIZATION; SOFT LITHOGRAPHY; ALGORITHM; GENERATION;
D O I
10.1145/3450504
中图分类号
TP301 [理论、方法];
学科分类号
081202 ;
摘要
As one of the most promising lab-on-a-chip systems, flow-based microfluidic biochips are being increasingly used for automatically executing various laboratory procedures in biology and biochemistry, such as enzymelinked immunosorbent assay, point-of-care diagnosis, and so on. As manufacturing technology advances, the characteristic dimensions of biochip systems keep shrinking, and tens of thousands of microvalves can now be integrated into a coin-sized microfluidic platform, making the conventional manual-based chip design no longer applicable. Accordingly, computer-aided design (CAD) of microfluidics has attracted considerable research interest in the EDA community over the past decade. This review article presents recent advances in the design automation of biochips, involving CAD techniques for architectural synthesis, wash optimization, testing, fault diagnosis, and fault-tolerant design. With the help of these CAD tools, chip designers can be released from the burden of complex, large-scale design tasks. Meanwhile, new chip architectures can be explored automatically to open new doors to meet requirements from future large-scale biological experiments and medical diagnosis. We discuss key trends and directions for future research that are related to enable microfluidics to reach its full potential, thus further advancing the development and progression of the microfluidics industry.
引用
收藏
页数:29
相关论文
共 113 条
[1]  
Ali SS, 2015, 2015 33RD IEEE INTERNATIONAL CONFERENCE ON COMPUTER DESIGN (ICCD), P483, DOI 10.1109/ICCD.2015.7357154
[2]   Computer-Aided Design for Microfluidic Chips Based on Multilayer Soft Lithography [J].
Amin, Nada ;
Thies, William ;
Amarasinghe, Saman .
2009 IEEE INTERNATIONAL CONFERENCE ON COMPUTER DESIGN, 2009, :2-+
[3]   Microfluidic very large scale integration (mVLSI) with integrated micromechanical valves [J].
Araci, Ismail Emre ;
Quake, Stephen R. .
LAB ON A CHIP, 2012, 12 (16) :2803-2806
[4]   Long-term monitoring of bacteria undergoing programmed population control in a microchemostat [J].
Balagaddé, FK ;
You, LC ;
Hansen, CL ;
Arnold, FH ;
Quake, SR .
SCIENCE, 2005, 309 (5731) :137-140
[5]   Efficient spanning-tree-based test pattern generation for Programmable Microfluidic Devices [J].
Bernardini, Alessandro ;
Liu, Chunfeng ;
Li, Bing ;
Schlichtmann, Ulf .
MICROELECTRONICS JOURNAL, 2018, 79 :38-45
[6]   Software aided failure analysis using ATPG tool [J].
Burmer, C ;
Egger, P .
PROCEEDINGS OF THE 2001 8TH INTERNATIONAL SYMPOSIUM ON THE PHYSICAL & FAILURE ANALYSIS OF INTEGRATED CIRCUITS, 2001, :210-215
[7]  
Chen ZS, 2019, DES AUT TEST EUROPE, P1525, DOI [10.23919/date.2019.8715269, 10.23919/DATE.2019.8715269]
[8]   Microfluidics-based diagnostics of infectious diseases in the developing world [J].
Chin, Curtis D. ;
Laksanasopin, Tassaneewan ;
Cheung, Yuk Kee ;
Steinmiller, David ;
Linder, Vincent ;
Parsa, Hesam ;
Wang, Jennifer ;
Moore, Hannah ;
Rouse, Robert ;
Umviligihozo, Gisele ;
Karita, Etienne ;
Mwambarangwe, Lambert ;
Braunstein, Sarah L. ;
van de Wijgert, Janneke ;
Sahabo, Ruben ;
Justman, Jessica E. ;
El-Sadr, Wafaa ;
Sia, Samuel K. .
NATURE MEDICINE, 2011, 17 (08) :1015-U138
[9]   Test of the rapid PCR method using AmpFlSTR Identifiler kit [J].
Choung, Chong Min ;
Lee, Dong Sub ;
Park, Ki Won ;
Han, Myun Soo .
FORENSIC SCIENCE INTERNATIONAL GENETICS SUPPLEMENT SERIES, 2011, 3 (01) :E475-E476
[10]   30 years of microfluidics [J].
Convery, Neil ;
Gadegaard, Nikolaj .
MICRO AND NANO ENGINEERING, 2019, 2 :76-91