Genetic analysis of norovirus GII.4 variants circulating in Korea in 2008

被引：26

作者：

Park, K. S. ^{[2
]}

Jeong, H. S. ^{[1
]}

Baek, K. A. ^{[2
]}

Lee, C. G. ^{[2
]}

Park, S. M. ^{[2
]}

Park, J. S. ^{[3
]}

Choi, Y. J. ^{[4
]}

Choi, H. J. ^{[5
]}

Cheon, D. S. ^{[1
]}

机构：

[1] Korea Ctr Dis Control & Prevent, Natl Inst Hlth, Ctr Infect Dis, Div Enter & Hepatitis Viruses,Dept Virol, Seoul 122701, South Korea

[2] Chungcheongnam Do Inst Hlth & Environm Res, Taejon, South Korea

[3] Soonchunhyang Univ, Dept Pediat, Cheonan, South Korea

[4] Soonchunhyang Univ, Coll Med, Dept Clin Pathol, Cheonan, South Korea

[5] Daejeon Hlth Sci Coll, Dept Food & Nutr, Taejon, South Korea

来源：

ARCHIVES OF VIROLOGY | 2010年 / 155卷 / 05期

关键词：

NORWALK-LIKE VIRUSES; ACUTE GASTROENTERITIS; MOLECULAR EPIDEMIOLOGY; VIRAL GASTROENTERITIS; UNITED-STATES; OUTBREAKS; STRAIN; IDENTIFICATION; SPREAD; INFECTIONS;

D O I：

10.1007/s00705-010-0627-y

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Noroviruses are the enteric pathogens most commonly responsible for infectious gastroenteritis and outbreaks of foodborne illness. The GII.4 norovirus, in particular, is responsible for the majority of epidemics. Here, we present data on the distribution of norovirus genotypes in Chungnam, Korea, in 2008, measure genetic variation among GII.4 strains, and compare Korean GII.4 variants with reference strains based on the 237-bp junction of ORF1 and ORF2. We detected 139 different strains, which formed two distinct genetic clusters with significant sequence diversity. One Korean cluster (2008-Korea_a) showed high similarity to the Sakai cluster that appeared in Japan and Europe in 2006. The other cluster (2008-Korea_b) was unique and unrelated to previously reported clusters. Genotype GII.4 was confirmed as the predominant cause of norovirus epidemics in Korea. Foodborne norovirus infections, on the other hand, were generally caused by emerging GII.4 genetic variants similar to those responsible for global epidemics.

引用

页码：635 / 641

页数：7

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