Leukemia inhibitory factor receptor (LIFR) is detected as a novel suppressor gene of hepatocellular carcinoma using double-combination array

被引：51
|
作者：
Okamura, Yukiyasu [1 ]
Nomoto, Shuji [1 ]
Kanda, Mitsuro [1 ]
Li, Qiyong [1 ]
Nishikawa, Yoko [1 ]
Sugimoto, Hiroyuki [1 ]
Kanazumi, Naohito [1 ]
Takeda, Shin [1 ]
Nakao, Akimasa [1 ]
机构：
[1] Nagoya Univ, Dept Surg 2, Grad Sch & Med, Showa Ku, Nagoya, Aichi 4668550, Japan
来源：
CANCER LETTERS | 2010年 / 289卷 / 02期
关键词：
Hepatocellular carcinoma; Leukemia inhibitory factor receptor; Tumor suppressor gene; Expression array; Single nucleotide polymorphism array; UNIPARENTAL DISOMY; EXPRESSION; MICROARRAY; OVEREXPRESSION; IDENTIFICATION; MUTATIONS; GENOME; CANCER; EVENT;
D O I：
10.1016/j.canlet.2009.08.013
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Hepatocellular carcinoma (HCC) is one of the world's top five causes of cancer-related deaths and treatment options are limited in this type of cancer. In the present study, we attempt to identify the novel suppressor genes of HCC using a double-combination array we designed. Leukemia inhibitory factor receptor (LIFR) is one of suppressor genes using this method. We found that 23 of 48 (47.9%) tumor tissues showed promoter hypermethylation of LIFR gene, and the expression level was clearly reduced in tumor tissues (P < 0.0001). The present study suggests that our method is a meaning technique able to detect novel genes and that LIFR gene is a new suppressor gene of HCC. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：170 / 177
页数：8
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