Circulating fetuin-A in patients with pancreatic cancer: a hospital-based case-control study

被引：11

作者：

Dalamaga, Maria ^{[1
]}

Polyzos, Stergios A. ^{[2
]}

Karmaniolas, Konstantinos ^{[3
]}

Chamberland, John ^{[2
]}

Lekka, Antigoni ^{[4
]}

Migdalis, Ilias ^{[3
]}

Papadavid, Evangelia ^{[5
]}

Dionyssiou-Asteriou, Amalia ^{[1
]}

Mantzoros, Christos S. ^{[4
,6
]}

机构：

[1] Univ Athens, Sch Med, Attikon Gen Univ Hosp, Dept Clin Biochem, GR-11527 Athens, Greece

[2] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Endocrinol Diabet & Metab, Boston, MA 02130 USA

[3] 417 Army Share Fund Gen Hosp, Dept Internal Med, Athens, Greece

[4] 417 Army Share Fund Gen Hosp, Hematol Lab, Athens, Greece

[5] Univ Athens, Attikon Gen Univ Hosp, Sch Med, Dermatol Clin,Dept Internal Med, Athens, Greece

[6] Harvard Univ, Sch Med, Boston VA Healthcare Syst, Endocrinol Sect, Boston, MA 02130 USA

来源：

BIOMARKERS | 2014年 / 19卷 / 08期

关键词：

Alpha-2-HS-glycoprotein; insulin; insulin resistance; leptin; malignancy; pancreas; MYELODYSPLASTIC-SYNDROME; INSULIN-RESISTANCE; ADIPONECTIN; GLYCOPROTEIN; LEPTIN; BREAST; RISK; ATHEROSCLEROSIS; PATHOGENESIS; PROTEINS;

D O I：

10.3109/1354750X.2014.974071

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Context: A proteomic analysis has proposed fetuin-A (alpha-2-HS-glycoprotein) as a new potential marker for pancreatic cancer (PC). Objective: Circulating fetuin-A levels in patients with PC. Methods: Serum fetuin-A was measured in 81 cases with PC and 81 matched controls before the initiation of any treatment. Results: Serum fetuin-A was not independently associated with the presence of PC. Although there was a trend with higher fetuin-A levels across PC stages, comparisons of fetuin-A in patients within different PC prognostic stages revealed no differences. Conclusions: Circulating fetuin-A was similar between patients and controls and was not associated with the disease severity.

引用

页码：660 / 666

页数：7

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