Product identification and the mechanisms involved in the transformation of cefazolin by birnessite (δ-MnO2)

被引：18

作者：

Li, Liping ^{[2
]}

Wei, Dongbin ^{[1
]}

Wei, Guohua

Du, Yuguo

机构：

[1] Chinese Acad Sci, State Key Lab Environm Chem & Ecotoxicol, Res Ctr Ecoenvironm Sci, Beijing 100085, Peoples R China

[2] Hong Kong Univ Sci & Technol, Div Environm, Kowloon, Hong Kong, Peoples R China

来源：

CHEMICAL ENGINEERING JOURNAL | 2017年 / 320卷

基金：

中国国家自然科学基金;

关键词：

Cefazolin; Manganese dioxide; beta-Lactam antibiotics; Transformation products; Oxidation mechanism; POWDER NEUTRON-DIFFRACTION; HEAVY-METAL RESISTANCE; MANGANESE OXIDE; ANTIBACTERIAL AGENTS; OXIDATIVE TRANSFORMATION; CRYSTAL-STRUCTURE; AQUEOUS-SOLUTION; ANTIBIOTICS; WATER; DEGRADATION;

D O I：

10.1016/j.cej.2017.03.021

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Cefazolin, a widely used cephalosporin antibiotic in human therapy, was the target in this study. Manganese dioxide, which is abundant in soils and sediments, is one of the most important natural oxidants and catalysts. To better understand the fate of cephalosporin antibiotics in natural soils and sediments, the transformation of cefazolin with manganese dioxide (delta-MnO2) was investigated. Four major transformation products formed via the oxidation of thioether and olefin, hydrolysis and acid-catalyzed decarboxylation were identified, and plausible transformation pathways were proposed. The formation of transformation product species was found to be pH dependent due to the different oxidation abilities of delta-MnO2 under different pH conditions. The sulfoxide-type products formed in this study were previously reported to exhibit high genotoxicity. Therefore, the potential ecological risk of cefazolin transformation in natural sediments and soils is sufficient to merit concern. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：116 / 123

页数：8

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