A novel antiviral intervention results in more accurate assessment of human immunodeficiency virus type 1 replication dynamics and T-Cell decay in vivo

被引：301

作者：

Markowitz, M

Louie, M

Hurley, A

Sun, E

Di Mascio, M

机构：

[1] Rockefeller Univ, Aaron Diamond AIDS Res Ctr, New York, NY 10016 USA

[2] Abbott Labs, Abbott Pk, IL 60064 USA

[3] Los Alamos Natl Lab, Div Theoret, Los Alamos, NM USA

来源：

JOURNAL OF VIROLOGY | 2003年 / 77卷 / 08期

关键词：

D O I：

10.1128/JVI.77.8.5037-5038.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Mathematical models provide an understanding of in vivo replication kinetics of human immunodeficiency virus type 1 (HIV-1). With a novel intervention designed for increased potency, we have more accurately deduced the half-lives of virus-producing CD4+ T cells, 0.7 day, and the generation time of HIV-1 in vivo, approximately 2 days, confirming the dynamic nature of HIV-1 replication.

引用

收藏

页码：5037 / 5038

页数：2

相关论文

共 7 条

[1] RAPID TURNOVER OF PLASMA VIRIONS AND CD4 LYMPHOCYTES IN HIV-1 INFECTION [J].

HO, DD ;

NEUMANN, AU ;

PERELSON, AS ;

CHEN, W ;

LEONARD, JM ;

MARKOWITZ, M .

NATURE, 1995, 373 (6510) :123-126

[2]

LOUIE M, IN PRESS J INFECT DI

[3] Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection [J].

Palella, FJ ;

Delaney, KM ;

Moorman, AC ;

Loveless, MO ;

Fuhrer, J ;

Satten, GA ;

Aschman, DJ ;

Holmberg, SD .

NEW ENGLAND JOURNAL OF MEDICINE, 1998, 338 (13) :853-860

[4] HIV-1 dynamics in vivo: Virion clearance rate, infected cell life-span, and viral generation time [J].

Perelson, AS ;

Neumann, AU ;

Markowitz, M ;

Leonard, JM ;

Ho, DD .

SCIENCE, 1996, 271 (5255) :1582-1586

[5] Decay characteristics of HIV-1-infected compartments during combination therapy [J].

Perelson, AS ;

Essunger, P ;

Cao, YZ ;

Vesanen, M ;

Hurley, A ;

Saksela, K ;

Markowitz, M ;

Ho, DD .

NATURE, 1997, 387 (6629) :188-191

[6] Rapid production and clearance of HIV-1 and hepatitis C virus assessed by large volume plasma apheresis [J].

Ramratnam, B ;

Bonhoeffer, S ;

Binley, J ;

Hurley, A ;

Zhang, LQ ;

Mittler, JE ;

Markowitz, M ;

Moore, JP ;

Perelson, AS ;

Ho, DD .

LANCET, 1999, 354 (9192) :1782-1785

[7] Antiretroviral treatment for adult HIV infection in 2002 - Updated recommendations of the international AIDS Society-USA panel [J].

Yeni, PG ;

Hammer, SM ;

Carpenter, CCJ ;

Cooper, DA ;

Fischl, MA ;

Gatell, JM ;

Gazzard, BG ;

Hirsch, MS ;

Jacobsen, DM ;

Katzenstein, DA ;

Montaner, JSG ;

Richman, DD ;

Saag, MS ;

Schechter, M ;

Schooley, RT ;

Thompson, MA ;

Vella, S ;

Volberding, PA .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2002, 288 (02) :222-235