Unravelling HP1 functions: post-transcriptional regulation of stem cell fate

被引：8
作者：
Casale, Assunta Maria [1 ]
Cappucci, Ugo [1 ]
Piacentini, Lucia [1 ]
机构：
[1] Sapienza Univ Rome, Dept Biol & Biotechnol C Darwin, Rome, Italy
来源：
CHROMOSOMA | 2021年 / 130卷 / 2-3期
关键词：
Heterochromatin protein 1; Heterochromatin; Post-transcriptional regulation of gene expression; Germline stem cells; Drosophila melanogaster; HETEROCHROMATIN PROTEIN-1 HP1; POSITION-EFFECT VARIEGATION; CHROME SHADOW DOMAIN; NONHISTONE CHROMOSOMAL-PROTEIN; HISTONE H3; DROSOPHILA-MELANOGASTER; GENE-EXPRESSION; PERICENTRIC HETEROCHROMATIN; LYSINE-9; METHYLATION; EUCHROMATIC REGIONS;
D O I：
10.1007/s00412-021-00760-1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Heterochromatin protein 1 (HP1) is a non-histone chromosomal protein first identified in Drosophila as a major component of constitutive heterochromatin, required for stable epigenetic gene silencing in many species including humans. Over the years, several studies have highlighted additional roles of HP1 in different cellular processes including telomere maintenance, DNA replication and repair, chromosome segregation and, surprisingly, positive regulation of gene expression. In this review, we briefly summarize past research and recent results supporting the unexpected and emerging role of HP1 in activating gene expression. In particular, we discuss the role of HP1 in post-transcriptional regulation of mRNA processing because it has proved decisive in the control of germline stem cells homeostasis in Drosophila and has certainly added a new dimension to our understanding on HP1 targeting and functions in epigenetic regulation of stem cell behaviour.
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页码：103 / 111
页数：9
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