Obstructive Sleep Apnea Syndrome and Metabolic Diseases

被引：102

作者：

Li, Min ^{[1
]}

Li, Xiaoying ^{[1
]}

Lu, Yan ^{[1
]}

机构：

[1] Fudan Univ, Zhongshan Hosp, Dept Endocrinol & Metab, 180 Fenglin Rd, Shanghai 200032, Peoples R China

来源：

ENDOCRINOLOGY | 2018年 / 159卷 / 07期

关键词：

NONALCOHOLIC FATTY LIVER; UNFOLDED PROTEIN RESPONSE; ADIPOSE-TISSUE; INTERMITTENT HYPOXIA; ER STRESS; OBESITY; ADIPONECTIN; LEPTIN; INFLAMMATION; PATHOPHYSIOLOGY;

D O I：

10.1210/en.2018-00248

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

With the rapid changes in lifestyle in modern society, including the high nutritional intake and reduced physical activity, the incidence of metabolic diseases has been increasing year by year. Obstructive sleep apnea syndrome (OSAS) is a sleep disorder, usually characterized by sudden pauses of breathing during sleep and an interrupted sleep rhythm. Although the pathological mechanism remains poorly understood, it has been strongly associated with metabolic diseases, including obesity, insulin resistance, type 2 diabetes mellitus (T2DM), and nonalcoholic fatty liver disease (NAFLD). In the present mini-review, we briefly summarize the connections between OSAS, obesity, T2DM, and NAFLD, which might help us to better understand the pathogenesis of human diseases.

引用

页码：2670 / 2675

页数：6

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