Background: The purpose of this study was to investigate the correlation between human epidermal growth factor receptor 2 (HER2) overexpression and clinicopathologic factors and overall survival rate in patients who underwent curative gastrectomy for gastric adenocarcinoma. Methods: Among patients who underwent curative gastrectomy for gastric adenocarcinoma at Inje University Paik Hospital from January 2012 to December 2015, 782 patients underwent an immunohistochemical analysis to evaluate HER2 expression levels. Clinicopathologic records that were collected from a gastric cancer database were retrospectively reviewed to identify clinicopathologic factors and survival rates of the patients. Results: HER2 overexpression was detected in 166 patients (21.2%). There was a statistically significant correlation between HER2 expression level and sex (p = 0.013), histologic differentiation (p < 0.001), Lauren classification (p < 0.001), and T pathologic stage (p = 0.022). There were no statistically significant relationships between HER2 expression level and overall 5-year survival rate (p = 0.775) and overall 5-year survival rate of gastric adenocarcinoma classified according to the TNM stage (stage I: p = 0.756, stage II: p = 0.571, stage III: p = 0.704). The HER2 expression level was not affected by the overall 5-year survival rate in the uni- and multivariate analyses. Conclusions: In this study, the HER2 overexpression rate in gastric adenocarcinoma was 21.2% and was observed in well- and moderately differentiated types according to histologic differentiation, intestinal type according to the Lauren classification, male, and low T stage. There was no correlation between HER2 expression level and overall 5-year survival rate, and HER2 expression level was not associated with independent prognostic factors.
机构:
Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul 110744, South KoreaSeoul Natl Univ, Coll Med, Dept Internal Med, Seoul 110744, South Korea
Bang, Yung-Jue
Kim, Young-Woo
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Natl Canc Ctr, Res Inst & Hosp, Gastr Canc Branch, Goyang Si, Gyeonggi Do, South KoreaSeoul Natl Univ, Coll Med, Dept Internal Med, Seoul 110744, South Korea
Kim, Young-Woo
Yang, Han-Kwang
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机构:
Seoul Natl Univ, Coll Med, Dept Surg, Seoul 110744, South KoreaSeoul Natl Univ, Coll Med, Dept Internal Med, Seoul 110744, South Korea
Yang, Han-Kwang
Chung, Hyun Cheol
论文数: 0引用数: 0
h-index: 0
机构:
Yonsei Univ, Coll Med, Metastasis Res Ctr, Yonsei Canc Ctr,Dept Med Oncol, Seoul 120749, South KoreaSeoul Natl Univ, Coll Med, Dept Internal Med, Seoul 110744, South Korea
Chung, Hyun Cheol
Park, Young-Kyu
论文数: 0引用数: 0
h-index: 0
机构:
Chonnam Natl Univ, Hwasun Hosp, Dept Surg, Jeonnam, South KoreaSeoul Natl Univ, Coll Med, Dept Internal Med, Seoul 110744, South Korea
Park, Young-Kyu
Lee, Kyung Hee
论文数: 0引用数: 0
h-index: 0
机构:
Yeungnam Univ, Coll Med, Taegu, South KoreaSeoul Natl Univ, Coll Med, Dept Internal Med, Seoul 110744, South Korea
Lee, Kyung Hee
Lee, Keun-Wook
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h-index: 0
机构:
Seoul Natl Univ, Bundang Hosp, Dept Internal Med, Songnam, Gyeonggi Do, South KoreaSeoul Natl Univ, Coll Med, Dept Internal Med, Seoul 110744, South Korea
Lee, Keun-Wook
Kim, Yong Ho
论文数: 0引用数: 0
h-index: 0
机构:
Kyung Hee Univ, Sch Med, Dept Surg, Seoul, South KoreaSeoul Natl Univ, Coll Med, Dept Internal Med, Seoul 110744, South Korea
Kim, Yong Ho
Noh, Sang-Ik
论文数: 0引用数: 0
h-index: 0
机构:
Seoul Vet Hosp, Dept Surg, Seoul, South KoreaSeoul Natl Univ, Coll Med, Dept Internal Med, Seoul 110744, South Korea
Noh, Sang-Ik
Cho, Jae Yong
论文数: 0引用数: 0
h-index: 0
机构:
Yonsei Univ, Coll Med, Metastasis Res Ctr, Yonsei Canc Ctr,Dept Med Oncol, Seoul 120749, South KoreaSeoul Natl Univ, Coll Med, Dept Internal Med, Seoul 110744, South Korea
Cho, Jae Yong
Mok, Young Jae
论文数: 0引用数: 0
h-index: 0
机构:
Korea Univ, Coll Med, Dept Surg, Seoul 136705, South KoreaSeoul Natl Univ, Coll Med, Dept Internal Med, Seoul 110744, South Korea
Mok, Young Jae
Kim, Yeul Hong
论文数: 0引用数: 0
h-index: 0
机构:
Korea Univ, Coll Med, Dept Internal Med, Seoul 136705, South KoreaSeoul Natl Univ, Coll Med, Dept Internal Med, Seoul 110744, South Korea
Kim, Yeul Hong
Ji, Jiafu
论文数: 0引用数: 0
h-index: 0
机构:
Beijing Canc Hosp, Beijing, Peoples R ChinaSeoul Natl Univ, Coll Med, Dept Internal Med, Seoul 110744, South Korea
Ji, Jiafu
Yeh, Ta-Sen
论文数: 0引用数: 0
h-index: 0
机构:
Chang Gung Mem Hosp Linkou, Dept Surg, Taipei, TaiwanSeoul Natl Univ, Coll Med, Dept Internal Med, Seoul 110744, South Korea
Yeh, Ta-Sen
Button, Peter
论文数: 0引用数: 0
h-index: 0
机构:
Infopeople, Sydney, NSW, AustraliaSeoul Natl Univ, Coll Med, Dept Internal Med, Seoul 110744, South Korea
Button, Peter
Sirzen, Florin
论文数: 0引用数: 0
h-index: 0
机构:
F Hoffmann La Roche, Basel, SwitzerlandSeoul Natl Univ, Coll Med, Dept Internal Med, Seoul 110744, South Korea
机构:
Hosp AC Camargo Fund Antonio Prudente, Dept Pathol, BR-01509900 Sao Paulo, BrazilHosp AC Camargo Fund Antonio Prudente, Dept Pathol, BR-01509900 Sao Paulo, Brazil
Begnami, Maria D.
Fukuda, Emy
论文数: 0引用数: 0
h-index: 0
机构:
Hosp AC Camargo Fund Antonio Prudente, Dept Pathol, BR-01509900 Sao Paulo, BrazilHosp AC Camargo Fund Antonio Prudente, Dept Pathol, BR-01509900 Sao Paulo, Brazil
Fukuda, Emy
Fregnani, Jose H. T. G.
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Canc Barretos, Barretos, BrazilHosp AC Camargo Fund Antonio Prudente, Dept Pathol, BR-01509900 Sao Paulo, Brazil
Fregnani, Jose H. T. G.
Nonogaki, Suely
论文数: 0引用数: 0
h-index: 0
机构:
Hosp AC Camargo Fund Antonio Prudente, Dept Pathol, BR-01509900 Sao Paulo, Brazil
Adolfo Lutz Inst, Sao Paulo, BrazilHosp AC Camargo Fund Antonio Prudente, Dept Pathol, BR-01509900 Sao Paulo, Brazil
Nonogaki, Suely
Montagnini, Andre L.
论文数: 0引用数: 0
h-index: 0
机构:
Hosp AC Camargo Fund Antonio Prudente, Dept Pathol, BR-01509900 Sao Paulo, BrazilHosp AC Camargo Fund Antonio Prudente, Dept Pathol, BR-01509900 Sao Paulo, Brazil
Montagnini, Andre L.
da Costa, Wilson L., Jr.
论文数: 0引用数: 0
h-index: 0
机构:
Hosp AC Camargo Fund Antonio Prudente, Dept Pathol, BR-01509900 Sao Paulo, BrazilHosp AC Camargo Fund Antonio Prudente, Dept Pathol, BR-01509900 Sao Paulo, Brazil
da Costa, Wilson L., Jr.
Soares, Fernando A.
论文数: 0引用数: 0
h-index: 0
机构:
Hosp AC Camargo Fund Antonio Prudente, Dept Pathol, BR-01509900 Sao Paulo, BrazilHosp AC Camargo Fund Antonio Prudente, Dept Pathol, BR-01509900 Sao Paulo, Brazil
机构:
Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul 110744, South KoreaSeoul Natl Univ, Coll Med, Dept Internal Med, Seoul 110744, South Korea
Bang, Yung-Jue
Kim, Young-Woo
论文数: 0引用数: 0
h-index: 0
机构:
Natl Canc Ctr, Res Inst & Hosp, Gastr Canc Branch, Goyang Si, Gyeonggi Do, South KoreaSeoul Natl Univ, Coll Med, Dept Internal Med, Seoul 110744, South Korea
Kim, Young-Woo
Yang, Han-Kwang
论文数: 0引用数: 0
h-index: 0
机构:
Seoul Natl Univ, Coll Med, Dept Surg, Seoul 110744, South KoreaSeoul Natl Univ, Coll Med, Dept Internal Med, Seoul 110744, South Korea
Yang, Han-Kwang
Chung, Hyun Cheol
论文数: 0引用数: 0
h-index: 0
机构:
Yonsei Univ, Coll Med, Metastasis Res Ctr, Yonsei Canc Ctr,Dept Med Oncol, Seoul 120749, South KoreaSeoul Natl Univ, Coll Med, Dept Internal Med, Seoul 110744, South Korea
Chung, Hyun Cheol
Park, Young-Kyu
论文数: 0引用数: 0
h-index: 0
机构:
Chonnam Natl Univ, Hwasun Hosp, Dept Surg, Jeonnam, South KoreaSeoul Natl Univ, Coll Med, Dept Internal Med, Seoul 110744, South Korea
Park, Young-Kyu
Lee, Kyung Hee
论文数: 0引用数: 0
h-index: 0
机构:
Yeungnam Univ, Coll Med, Taegu, South KoreaSeoul Natl Univ, Coll Med, Dept Internal Med, Seoul 110744, South Korea
Lee, Kyung Hee
Lee, Keun-Wook
论文数: 0引用数: 0
h-index: 0
机构:
Seoul Natl Univ, Bundang Hosp, Dept Internal Med, Songnam, Gyeonggi Do, South KoreaSeoul Natl Univ, Coll Med, Dept Internal Med, Seoul 110744, South Korea
Lee, Keun-Wook
Kim, Yong Ho
论文数: 0引用数: 0
h-index: 0
机构:
Kyung Hee Univ, Sch Med, Dept Surg, Seoul, South KoreaSeoul Natl Univ, Coll Med, Dept Internal Med, Seoul 110744, South Korea
Kim, Yong Ho
Noh, Sang-Ik
论文数: 0引用数: 0
h-index: 0
机构:
Seoul Vet Hosp, Dept Surg, Seoul, South KoreaSeoul Natl Univ, Coll Med, Dept Internal Med, Seoul 110744, South Korea
Noh, Sang-Ik
Cho, Jae Yong
论文数: 0引用数: 0
h-index: 0
机构:
Yonsei Univ, Coll Med, Metastasis Res Ctr, Yonsei Canc Ctr,Dept Med Oncol, Seoul 120749, South KoreaSeoul Natl Univ, Coll Med, Dept Internal Med, Seoul 110744, South Korea
Cho, Jae Yong
Mok, Young Jae
论文数: 0引用数: 0
h-index: 0
机构:
Korea Univ, Coll Med, Dept Surg, Seoul 136705, South KoreaSeoul Natl Univ, Coll Med, Dept Internal Med, Seoul 110744, South Korea
Mok, Young Jae
Kim, Yeul Hong
论文数: 0引用数: 0
h-index: 0
机构:
Korea Univ, Coll Med, Dept Internal Med, Seoul 136705, South KoreaSeoul Natl Univ, Coll Med, Dept Internal Med, Seoul 110744, South Korea
Kim, Yeul Hong
Ji, Jiafu
论文数: 0引用数: 0
h-index: 0
机构:
Beijing Canc Hosp, Beijing, Peoples R ChinaSeoul Natl Univ, Coll Med, Dept Internal Med, Seoul 110744, South Korea
Ji, Jiafu
Yeh, Ta-Sen
论文数: 0引用数: 0
h-index: 0
机构:
Chang Gung Mem Hosp Linkou, Dept Surg, Taipei, TaiwanSeoul Natl Univ, Coll Med, Dept Internal Med, Seoul 110744, South Korea
Yeh, Ta-Sen
Button, Peter
论文数: 0引用数: 0
h-index: 0
机构:
Infopeople, Sydney, NSW, AustraliaSeoul Natl Univ, Coll Med, Dept Internal Med, Seoul 110744, South Korea
Button, Peter
Sirzen, Florin
论文数: 0引用数: 0
h-index: 0
机构:
F Hoffmann La Roche, Basel, SwitzerlandSeoul Natl Univ, Coll Med, Dept Internal Med, Seoul 110744, South Korea
机构:
Hosp AC Camargo Fund Antonio Prudente, Dept Pathol, BR-01509900 Sao Paulo, BrazilHosp AC Camargo Fund Antonio Prudente, Dept Pathol, BR-01509900 Sao Paulo, Brazil
Begnami, Maria D.
Fukuda, Emy
论文数: 0引用数: 0
h-index: 0
机构:
Hosp AC Camargo Fund Antonio Prudente, Dept Pathol, BR-01509900 Sao Paulo, BrazilHosp AC Camargo Fund Antonio Prudente, Dept Pathol, BR-01509900 Sao Paulo, Brazil
Fukuda, Emy
Fregnani, Jose H. T. G.
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Canc Barretos, Barretos, BrazilHosp AC Camargo Fund Antonio Prudente, Dept Pathol, BR-01509900 Sao Paulo, Brazil
Fregnani, Jose H. T. G.
Nonogaki, Suely
论文数: 0引用数: 0
h-index: 0
机构:
Hosp AC Camargo Fund Antonio Prudente, Dept Pathol, BR-01509900 Sao Paulo, Brazil
Adolfo Lutz Inst, Sao Paulo, BrazilHosp AC Camargo Fund Antonio Prudente, Dept Pathol, BR-01509900 Sao Paulo, Brazil
Nonogaki, Suely
Montagnini, Andre L.
论文数: 0引用数: 0
h-index: 0
机构:
Hosp AC Camargo Fund Antonio Prudente, Dept Pathol, BR-01509900 Sao Paulo, BrazilHosp AC Camargo Fund Antonio Prudente, Dept Pathol, BR-01509900 Sao Paulo, Brazil
Montagnini, Andre L.
da Costa, Wilson L., Jr.
论文数: 0引用数: 0
h-index: 0
机构:
Hosp AC Camargo Fund Antonio Prudente, Dept Pathol, BR-01509900 Sao Paulo, BrazilHosp AC Camargo Fund Antonio Prudente, Dept Pathol, BR-01509900 Sao Paulo, Brazil
da Costa, Wilson L., Jr.
Soares, Fernando A.
论文数: 0引用数: 0
h-index: 0
机构:
Hosp AC Camargo Fund Antonio Prudente, Dept Pathol, BR-01509900 Sao Paulo, BrazilHosp AC Camargo Fund Antonio Prudente, Dept Pathol, BR-01509900 Sao Paulo, Brazil