Stimuli-sensitive drug delivery systems for site-specific antibiotic release

被引：29
作者：
Nazir, Faiqa [1 ,2 ]
Tabish, Tanveer A. [3 ]
Tariq, Fatima [1 ]
Iftikhar, Shanza [1 ]
Wasim, Rijja [1 ]
Shahnaz, Gul [1 ]
机构：
[1] Bilkent Univ, Inst Mat Sci & Nanotechnol, UNAM, TR-06800 Ankara, Turkey
[2] Imperial Coll London, London Ctr Nanotechnol, Dept Mat, London SW7 2AZ, England
[3] Quaid i Azam Univ, Fac Biol Sci, Dept Pharm, Islamabad 45320, Pakistan
来源：
DRUG DISCOVERY TODAY | 2022年 / 27卷 / 06期
关键词：
External stimuli-responsive drug delivery; Internal stimuli-responsive drug delivery; Targeted drug delivery; Antibiotic release; Nanoparticles; NANOPARTICLES; CIPROFLOXACIN; POLYMERS; THERAPY;
D O I：
10.1016/j.drudis.2022.02.014
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Site-specific delivery of antibiotics has always been a high-priority area in pharmaceutical research. Conventionally used antibiotics suffer several limitations, such as low accumulation and penetration in diseased cells/tissues, limited bioavailability of drugs, drug resistance, and off-target toxicity. To overcome these limitations, several strategies have been exploited for delivering antibiotics to the site of infection, such as the use of stimuli-responsive antibiotic delivery systems, which can release antibiotics in a controlled and timely fashion. These stimuli can either be exogenous (light, magnetism, ultrasound, and electrical) or endogenous (pH, redox reactions, and enzymatic). In this review, we present a summary of recent developments in the field of stimuli-based targeted drug delivery systems for the site-specific release of antibiotics.
引用
收藏
页码：1698 / 1705
页数：8
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