Synthesis and biological activities of dithiocarbamates containing 2(5H)-furanone-piperazine

被引：47

作者：

Wei, Meng-Xue ^{[1
]}

Zhang, Jiao ^{[1
]}

Ma, Fu-Li ^{[1
]}

Li, Ming ^{[1
]}

Yu, Jia-Ying ^{[1
]}

Luo, Wei ^{[1
]}

Li, Xue-Qiang ^{[1
]}

机构：

[1] Ningxia Univ, Sch Chem & Chem Engn, State Key Lab High Efficiency Utilizat Coal & Gre, Yinchuan 750021, Peoples R China

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2018年 / 155卷

基金：

中国国家自然科学基金;

关键词：

2(5H)-Furanone; Dithiocarbamates; Synthesis; Biological activities; SMMC-7721 cell lines; VITRO ANTICANCER ACTIVITY; ANTITUMOR ACTIVITIES; ANTIFUNGAL ACTIVITY; DERIVATIVES; AGENTS; ANALOGS; ACID; DESIGN; CANCER;

D O I：

10.1016/j.ejmech.2018.05.056

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of new dithiocarbamates containing a 2(5H)-furanone-piperazine group was synthesized. These compounds show good in vitro cytoxic activity. Among them, compound 6c exhibits the best inhibitory activity against HeLa cell lines with an IC50 of 0.06 +/- 0.01 mu M for 72 h, and it has good inhibitory activity against SMMC-7721 cell lines with an IC50 of 0.006 +/- 0.04 mu M for 72 h, but the toxicity was lower against LO2 cell lines with an IC50 of 45.76 +/- 0.01 mu M. The result showed that compound 6c is far more cytoxic towards cancer cell lines than towards benign cell lines compared with cytosine arabinoside (ARA) in vitro. (C) 2018 Elsevier Masson SAS. All rights reserved.

引用

页码：165 / 170

页数：6

共 50 条

[21] Synthesis and Biological Activity of Novel N-glucosides Containing Substituted Piperazine Moiety
Zhang, Li-Yuan
Wang, Bao-Lei
Zhan, Yi-Zhou
Hua, Xue-Wen
Liu, Ming
Zhang, Xiao
Song, Hai-Bin
Li, Zheng-Ming
LETTERS IN DRUG DESIGN & DISCOVERY, 2016, 13 (04) : 343 - 351
[22] SYNTHESIS OF 2(5H)-FURANONE DERIVATIVES WITH SYMMETRICAL AND UNSYMMETRICAL BIS-1,2,3-TRIAZOLE STRUCTURE
Tan, Yuehe
Li, Jianxiao
Huo, Jingpei
Xue, Fuling
Wang, Zhaoyang
SYNTHETIC COMMUNICATIONS, 2014, 44 (20) : 2974 - 2987
[23] First example of the synthesis of S,O-macroheterocycle based on 2(5H)-furanone and 2,2′-oxydiethanethiol
Kurbangalieva, A. R.
Hoang, L. T.
Lodochnikova, O. A.
Kuzmicheva, M. Yu.
Pradipta, A. R.
Tanaka, K.
Chmutova, G. A.
RUSSIAN CHEMICAL BULLETIN, 2016, 65 (05) : 1278 - 1284
[24] Synthesis and biological evaluation of estrone 3-O-ether derivatives containing the piperazine moiety
Chen, Hong
Liang, Xue
Sun, Tao
Qiao, Xiaoguang
Zhou, Zhan
Li, Ziyong
He, Chaojun
Ya, Huiyuan
Yuan, Mu
STEROIDS, 2018, 134 : 101 - 109
[25] Reaction of 5(R)-(l-Menthoxy)-2(5H)-furanone with Diethyl Bromomalonate
Kang, Haixia
Bai, Jing
Xi, Zhentao
Zhang, Manman
Fu, Yuqin
Zou, Dapeng
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2016, 36 (08) : 1915 - 1920
[26] Design and Synthesis of 4-Fluorophenyl-5-methylene-2(5H)-furanone Derivatives as Potent Quorum Sensing Inhibitors
Zhang, Panpan
Chen, Weijin
Ma, Yang-Chun
Bai, Bingfang
Sun, Guanglin
Zhang, Shenyan
Chang, Xiaohong
Wang, Yingmei
Jiang, Nan
Zhang, Xianghui
Ma, Shutao
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 66 (13) : 8441 - 8463
[27] Synthesis and Biological Activities of 10-Substituted 9-Aryl-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H)-diones
Wang Fang-Ming
Hu Bing-Xiang
Chen Chuan-Xiang
Zhou Ze-Yu
Bao Dan
Chen Li-Zhuang
CHINESE JOURNAL OF STRUCTURAL CHEMISTRY, 2016, 35 (03) : 442 - 448
[28] Synthesis and antibacterial activities of 5-hydroxy-4-amino-2(5H)-furanones
Lattmann, E
Dunn, S
Niamsanit, S
Sattayasai, N
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (04) : 919 - 921
[29] Design and synthesis of 2(5H)-furanone liquid-crystal compounds based on natural molecules and biphenyl derivatives
Shi-He Luo
Jin-Feng Xiong
Zhao-Yang Wang
Guang-Zhen Mo
Research on Chemical Intermediates, 2013, 39 : 1865 - 1876
[30] Synthesis and biological activities of novel 1,2,4-triazole thiones and bis(1,2,4-triazole thiones) containing phenylpyrazole and piperazine moieties
Wang, Bao-Lei
Zhang, Li-Yuan
Zhan, Yi-Zhou
Zhang, Yan
Zhang, Xiao
Wang, Li-Zhong
Li, Zheng-Ming
JOURNAL OF FLUORINE CHEMISTRY, 2016, 184 : 36 - 44

← 1 2 3 4 5 →