Synthesis and biological activities of dithiocarbamates containing 2(5H)-furanone-piperazine

被引：47
|
作者：
Wei, Meng-Xue [1 ]
Zhang, Jiao [1 ]
Ma, Fu-Li [1 ]
Li, Ming [1 ]
Yu, Jia-Ying [1 ]
Luo, Wei [1 ]
Li, Xue-Qiang [1 ]
机构：
[1] Ningxia Univ, Sch Chem & Chem Engn, State Key Lab High Efficiency Utilizat Coal & Gre, Yinchuan 750021, Peoples R China
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2018年 / 155卷
基金：
中国国家自然科学基金;
关键词：
2(5H)-Furanone; Dithiocarbamates; Synthesis; Biological activities; SMMC-7721 cell lines; VITRO ANTICANCER ACTIVITY; ANTITUMOR ACTIVITIES; ANTIFUNGAL ACTIVITY; DERIVATIVES; AGENTS; ANALOGS; ACID; DESIGN; CANCER;
D O I：
10.1016/j.ejmech.2018.05.056
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of new dithiocarbamates containing a 2(5H)-furanone-piperazine group was synthesized. These compounds show good in vitro cytoxic activity. Among them, compound 6c exhibits the best inhibitory activity against HeLa cell lines with an IC50 of 0.06 +/- 0.01 mu M for 72 h, and it has good inhibitory activity against SMMC-7721 cell lines with an IC50 of 0.006 +/- 0.04 mu M for 72 h, but the toxicity was lower against LO2 cell lines with an IC50 of 45.76 +/- 0.01 mu M. The result showed that compound 6c is far more cytoxic towards cancer cell lines than towards benign cell lines compared with cytosine arabinoside (ARA) in vitro. (C) 2018 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：165 / 170
页数：6
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