The Role of Glycinergic Transmission in the Pathogenesis of Alcohol Abuse

被引:0
作者
Zakowicz, Przemyslaw [1 ]
Kujawski, Radoslaw [1 ]
Mikolajczak, Przemyslaw [1 ]
机构
[1] Poznan Univ Med Sci, Dept Pharmacol, Ul Rokietnicka 5a, PL-60806 Poznan, Poland
来源
POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ | 2018年 / 72卷
关键词
Ethanol; Addiction; Glycine Receptors; VENTRAL TEGMENTAL AREA; G-BETA-GAMMA; NUCLEUS-ACCUMBENS; MOLECULAR PHARMACOLOGY; REWARD SYSTEM; ETHANOL; RECEPTORS; MODULATION; POTENTIATION; SENSITIVITY;
D O I
10.5604/01.3001.0012.1736
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Alcoholism is a severe social and medical problem. Inadequate ethanol (EtOH) consumption results in acute and chronic conditions, which lead to many hospitalizations and generate considerable costs in healthcare. Alcoholism undoubtedly needs to be thoroughly described, especially in relation to the molecular mechanism of addiction. The current opinion about the pathogenesis of EtOH abuse is mainly based on the dopaminergic theory of addiction, connected with the impaired function of the dopaminergic transmission in the brain's reward system. Moreover, recent evidence suggests that the potential role in alcohol activity is played also by glycinergic transmission, based inter alia on inhibitory glycine receptors (GlyRs) sensitive to this simplest amino acid. GlyRs are pentameric, ionotropic receptors from ligand-gated ion channel family and facilitate membrane permeability to chloride ions. The receptors are widely present in the human body and spread to the peripheral and central nervous system, where they are engaged in several processes, especially in the regulation of nociception, movement control and, possibly, also they are responsible for controlling the brain's reward system involved in the pathogenesis of addiction. The last localization seems to be really important and consists of a new insight into the search for novel substances to prevent or cure the consequences of EtOH abuse. In this paper describes recently discovered and animal-tested ligands, which may be an interesting tool in the treatment of alcohol-related syndromes.
引用
收藏
页码:587 / 593
页数:7
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