Synthesis of camptothecin-loaded gold nanomaterials

被引：8

作者：

Xing, Zhimin ^{[1
,2
]}

Liu, Zhiguo ^{[1
,2
]}

Zu, Yuangang ^{[1
,2
]}

Fu, Yujie ^{[1
,2
]}

Zhao, Chunjian ^{[1
,2
]}

Zhao, Xiuhua ^{[1
,2
]}

Meng, Ronghua ^{[1
,2
]}

Tan, Shengnan ^{[1
,2
]}

机构：

[1] NE Forestry Univ, Minist Educ, Key Lab Forest Plant Ecol, Harbin 150040, Peoples R China

[2] NE Forestry Univ, Minist Educ, Engn Res Ctr Forest Biopreparat, Harbin 150040, Peoples R China

来源：

APPLIED SURFACE SCIENCE | 2010年 / 256卷 / 12期

关键词：

Gold nanoparticles; Gold nanochains; Camptothecin; CPT; TEM; AFM; ANTITUMOR CHARACTERISTICS; NANOPARTICLES; NANOSTRUCTURES; NANOCRYSTALS; FABRICATION; HYDROLYSIS; REDUCTION; INTERFACE; NANOWIRES; CHEMISTRY;

D O I：

10.1016/j.apsusc.2010.01.050

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Camptothecin-loaded gold nanomaterials have been synthesized by the sodium borohydride reduction method under a strong basic condition. The obtained gold nanomaterials have been characterized by transmission electron microscopy (TEM), atomic force microscopy (AFM) and UV-vis absorption spectroscopy. The camptothecin-loaded gold colloidal solution was very stable and can be stored for more than two months at room temperature without obvious changes. The color of the colloidal solution can change from wine red to purple and blue during the acidifying process. It was revealed that the release of camptothecin and the aggregation of gold nanoparticles can be controlled by tuning the solution pH. The present study implied that the gold nanomaterials can be used as the potential carrier for CPT delivery. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：3917 / 3920

页数：4

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