Chemotherapy of advanced non small cell lung cancer in the elderly: an update

被引：19

作者：

Gridelli, C ^{[1
]}

机构：

[1] Ist Nazl Tumori, Div Oncol Med B, I-80131 Naples, Italy

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2000年 / 35卷 / 03期

关键词：

elderly; NSCLC; phase III; ELVIS;

D O I：

10.1016/S1040-8428(99)00064-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In the last years there has been a glowing awareness in the oncological community about the size of the problem of cancer in the elderly. Mole than 30% of lung cancers arise in patients aged 70 years or more. Elderly patients tolerate chemotherapy poorly and are not considered eligible for aggressive cisplatin based chemotherapy in clinical practice. A few papers have been published on chemotherapy of elderly NSCLC patients. Cisplatin based chemotherapy seems to be tolerated poorly. Vinorelbine as a single agent showed active and good tolerance. A phase III randomized trial, named ELVIS (Elderly Lung Cancer Vinorelbine Italian Study), showed a survival and quality of life benefit of vinorelbine versus supportive care. Among the new drugs gemcitabine can be considered more promising. Future trials should attempt to improve the results of vinorelbine chemotherapy and include geriatric and quality of life evaluations. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：219 / 225

页数：7

共 45 条

[1] THE EUROPEAN-ORGANIZATION-FOR-RESEARCH-AND-TREATMENT-OF-CANCER QLQ-C30 - A QUALITY-OF-LIFE INSTRUMENT FOR USE IN INTERNATIONAL CLINICAL-TRIALS IN ONCOLOGY [J].

AARONSON, NK ;

AHMEDZAI, S ;

BERGMAN, B ;

BULLINGER, M ;

CULL, A ;

DUEZ, NJ ;

FILIBERTI, A ;

FLECHTNER, H ;

FLEISHMAN, SB ;

DEHAES, JCJM ;

KAASA, S ;

KLEE, M ;

OSOBA, D ;

RAZAVI, D ;

ROFE, PB ;

SCHRAUB, S ;

SNEEUW, K ;

SULLIVAN, M ;

TAKEDA, F .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1993, 85 (05) :365-376

[2]

ABRAM M, 1985, RECENT ADV GERIATRIC, V3, P217

[3]

ALBERTI W, 1995, BRIT MED J, V311, P899

[4] Phase II study of oral doxifluridine in elderly patients with advanced non-small-cell lung cancer [J].

Baldini, E ;

Tibaldi, C ;

Pfanner, E ;

Ricci, S ;

Falcone, A ;

Ceribelli, A ;

Sarcina, R ;

Comella, G ;

Stampino, CG ;

Conte, PF .

AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, 1996, 19 (06) :592-594

[5] Age and the treatment of lung cancer [J].

Brown, JS ;

Eraut, D ;

Trask, C ;

Davison, AG .

THORAX, 1996, 51 (06) :564-568

[6] WEEKLY VINORELBINE IN ELDERLY PATIENTS WITH NON-SMALL-CELL LUNG-CANCER [J].

COLLEONI, M ;

GAION, F ;

NELLI, P ;

COLMELLERE, GM ;

MANENTE, P .

TUMORI, 1994, 80 (06) :448-452

[7]

COLLEONI M, 1996, 6 INT C ANT TREATM P

[8] The role of vindesine and lonidamine in the treatment of elderly patients with advanced non-small cell lung cancer: A phase III randomized FONICAP trial [J].

De Marinis, F ;

Rinaldi, M ;

Ardizzoni, A ;

Bruzzi, P ;

Pennucci, MC ;

Portalone, L ;

D'Aprile, M ;

Ripanti, P ;

Romano, F ;

Belli, M ;

Altavilla, G ;

Migliorino, MR ;

Rosso, R ;

Salvati, F .

TUMORI, 1999, 85 (03) :177-182

[9]

Feliu J, 1999, CANCER-AM CANCER SOC, V86, P1463, DOI 10.1002/(SICI)1097-0142(19991015)86:8<1463::AID-CNCR12>3.0.CO

[10]

2-N

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