The ART of tumor immune escape

被引：10
作者：
Wennerberg, Erik [1 ]
Mukherjee, Sumit [2 ]
Sainz, Ricardo M. [1 ]
Stiles, Brendon M. [2 ]
机构：
[1] Inst Canc Res, Div Radiotherapy & Imaging, London, England
[2] Albert Einstein Coll Med, Dept Cardiothorac & Vasc Surg, Bronx, NY 10461 USA
来源：
ONCOIMMUNOLOGY | 2022年 / 11卷 / 01期
关键词：
mono-ADP-ribosylation; immune escape; CD8 T cells; NAD-induced cell death; CD38; lung cancer; RECEPTOR; CELLS; DEATH;
D O I：
10.1080/2162402X.2022.2076310
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We recently identified the adenosine-5'-diphosphate (ADP)-ribosyltransferase-1 (ART1) as a novel immune checkpoint expressed by cancer cells. ART1 utilizes free nicotinamide adenine dinucleotide (NAD(+)) in the tumor microenvironment (TME) to mono-ADP-ribosylate (MARylate) the P2X7 receptor (P2X7R) on CD8 T cells, resulting in NAD-induced cell death (NICD) and tumor immune resistance. This process is blocked by therapeutic antibody targeting of ART1.
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