Role of islet microRNAs in diabetes: which model for which question?

被引:36
作者
Guay, Claudiane [1 ]
Regazzi, Romano [1 ]
机构
[1] Univ Lausanne, Fac Biol & Med, Dept Fundamental Neurosci, CH-1005 Lausanne, Switzerland
关键词
Animal models of Diabetes; Diabetes; Human islet donors; Insulin; Islets of Langerhans; MicroRNAs; Pancreatic beta cells; Review; BETA-CELL FAILURE; INSULIN TRANSCRIPTION; DOWN-REGULATION; EXPRESSION; INDIVIDUALS; METABOLISM; CONTRIBUTE; EXPANSION; MIR-7;
D O I
10.1007/s00125-014-3471-x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
MicroRNAs are important regulators of gene expression. The vast majority of the cells in our body rely on hundreds of these tiny non-coding RNA molecules to precisely adjust their protein repertoire and faithfully accomplish their tasks. Indeed, alterations in the microRNA profile can lead to cellular dysfunction that favours the appearance of several diseases. A specific set of microRNAs plays a crucial role in pancreatic beta cell differentiation and is essential for the fine-tuning of insulin secretion and for compensatory beta cell mass expansion in response to insulin resistance. Recently, several independent studies reported alterations in microRNA levels in the islets of animal models of diabetes and in islets isolated from diabetic patients. Surprisingly, many of the changes in microRNA expression observed in animal models of diabetes were not detected in the islets of diabetic patients and vice versa. These findings are unlikely to merely reflect species differences because microRNAs are highly conserved in mammals. These puzzling results are most probably explained by fundamental differences in the experimental approaches which selectively highlight the microRNAs directly contributing to diabetes development, the microRNAs predisposing individuals to the disease or the microRNAs displaying expression changes subsequent to the development of diabetes. In this review we will highlight the suitability of the different models for addressing each of these questions and propose future strategies that should allow us to obtain a better understanding of the contribution of microRNAs to the development of diabetes mellitus in humans.
引用
收藏
页码:456 / 463
页数:8
相关论文
共 45 条
  • [1] MicroRNAs: Target Recognition and Regulatory Functions
    Bartel, David P.
    [J]. CELL, 2009, 136 (02) : 215 - 233
  • [2] Differences in islet-enriched miRNAs in healthy and glucose intolerant human subjects
    Bolmeson, Caroline
    Esguerra, Jonathan L. S.
    Salehi, Albert
    Speidel, Dina
    Eliasson, Lena
    Cilio, Corrado M.
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2011, 404 (01) : 16 - 22
  • [3] Quantitative differential expression analysis reveals miR-7 as major islet microRNA
    Bravo-Egana, Valia
    Rosero, Samuel
    Molano, R. Damaris
    Pileggi, Antonello
    Ricordi, Camillo
    Dominguez-Bendala, Juan
    Pastori, Ricardo L.
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2008, 366 (04) : 922 - 926
  • [4] MicroRNAs and Metabolism Crosstalk in Energy Homeostasis
    Dumortier, Olivier
    Hinault, Charlotte
    Van Obberghen, Emmanuel
    [J]. CELL METABOLISM, 2013, 18 (03) : 312 - 324
  • [5] miR-375 targets 3'-phosphoinositide-dependent protein kinase-1 and regulates glucose-induced biological responses in pancreatic β-cells
    El Ouaamari, Abdelfattah
    Baroukh, Nadine
    Martens, Geert A.
    Lebrun, Patricia
    Pipeleers, Daniel
    van Obberghen, Emmanuel
    [J]. DIABETES, 2008, 57 (10) : 2708 - 2717
  • [6] INVITED REVIEW Role of non-coding RNAs in pancreatic beta-cell development and physiology
    Eliasson, L.
    Esguerra, J. L. S.
    [J]. ACTA PHYSIOLOGICA, 2014, 211 (02) : 273 - 284
  • [7] Differential Glucose-Regulation of MicroRNAs in Pancreatic Islets of Non-Obese Type 2 Diabetes Model Goto-Kakizaki Rat
    Esguerra, Jonathan Lou S.
    Bolmeson, Caroline
    Cilio, Corrado M.
    Eliasson, Lena
    [J]. PLOS ONE, 2011, 6 (04):
  • [8] Control of glucose homeostasis and insulin sensitivity by the Let-7 family of microRNAs
    Frost, Robert J. A.
    Olson, Eric N.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (52) : 21075 - 21080
  • [9] Diabetes mellitus, a microRNA-related disease?
    Guay, Claudiane
    Roggli, Elodie
    Nesca, Valeria
    Jacovetti, Cecile
    Regazzi, Romano
    [J]. TRANSLATIONAL RESEARCH, 2011, 157 (04) : 253 - 264
  • [10] MicroRNAs contribute to compensatory β cell expansion during pregnancy and obesity
    Jacovetti, Cecile
    Abderrahmani, Amar
    Parnaud, Geraldine
    Jonas, Jean-Christophe
    Peyot, Marie-Line
    Cornu, Marion
    Laybutt, Ross
    Meugnier, Emmanuelle
    Rome, Sophie
    Thorens, Bernard
    Prentki, Marc
    Bosco, Domenico
    Regazzi, Romano
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2012, 122 (10) : 3541 - 3551