IL-1β suppresses nephronectin expression in osteoblasts via ERK1/2 and JNK

被引：5

作者：

Iezumi, Yuka ^{[1
]}

Yamada, Atsushi ^{[1
]}

Minami, Erika ^{[1
]}

Ikehata, Mikiko ^{[1
,2
]}

Yoshida, Yuko ^{[1
,3
]}

Kato, Tadashi ^{[1
,4
]}

Morimura, Naoko ^{[5
]}

Ogata, Hiroaki ^{[4
]}

Sakashita, Akiko ^{[4
]}

Iijima, Takehiko ^{[3
]}

Chikazu, Daichi ^{[2
]}

Kamijo, Ryutaro ^{[1
]}

机构：

[1] Showa Univ, Sch Dent, Dept Biochem, Tokyo, Japan

[2] Tokyo Med Univ, Dept Oral & Maxillofacial Surg, Tokyo, Japan

[3] Showa Univ, Sch Dent, Dept Perioperat Med, Div Anesthesiol, Tokyo, Japan

[4] Showa Univ, Northern Yokohama Hosp, Dept Internal Med, Yokohama, Kanagawa, Japan

[5] Shiga Univ Med Sci, Dept Integrat Physiol, Shiga, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2017年 / 493卷 / 01期

基金：

日本学术振兴会;

关键词：

Osteoblasts; IL-1; beta; Nephronectin; PROTEIN NEPHRONECTIN; INTEGRIN; INTERLEUKIN-1; KIDNEY; POEM;

D O I：

10.1016/j.bbrc.2017.08.104

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nephronectin (Npnt), an extracellular matrix protein, is considered to play critical roles in development of various tissues and their functions. In basic science experiments, we found that interleukin-1 beta (IL-1 beta), well known to have an important role in inflammatory response, inhibited Npnt gene expression in MOT3-E1 cells, a mouse osteoblastic cell line. The purpose of this study was to investigate mechanisms that govern the regulation of Npnt gene expression by IL-1 beta in osteoblasts. (C) 2017 Elsevier Inc. All rights reserved.

引用

页码：773 / 775

页数：3

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