Structure elucidation and antitumour activity of a new macrolactam produced by marine-derived actinomycete Micromonospora sp FIM05328

被引：22

作者：

Nie, Yi-Lei ^{[1
]}

Wu, Yun-Dan ^{[1
,2
]}

Wang, Chuan-Xi ^{[1
]}

Lin, Ru ^{[1
]}

Xie, Yang ^{[1
]}

Fang, Dong-Sheng ^{[1
]}

Jiang, Hong ^{[1
]}

Lian, Yun-Yang ^{[1
]}

机构：

[1] Fujian Inst Microbiol, Fujian Prov Key Lab Screening Novel Microbial Pro, Fuzhou, Fujian, Peoples R China

[2] Third Peoples Hosp Fujian Prov, Fuzhou 350007, Fujian, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2018年 / 32卷 / 18期

关键词：

Micromonospora; macrolactam; aurodox; antitumour activity; ANTIBIOTICS; FERMENTATION; DIVERSITY; STRAINS;

D O I：

10.1080/14786419.2017.1366479

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Chemical investigation of a marine-derived actinomycete strain Micromonospora sp. FIM05328 isolated from a soil sample collected from the East China Sea, resulted in the discovery of a new 26-membered polyene macrolactam metabolite FW05328-1 (1), together with a known polyene with pyridone ring compound aurodox (2). The structures of compounds 1 and 2 were determined by the detailed analysis of 1D, 2D NMR and HR-TOF-MS data, along with literature data analysis. 1 and 2 exhibited excellent antiproliferative activities against KYSE30, KYSE180 and EC109 human tumour cell lines, but displayed no antibacterial activities against bacteria or fungi were tested. [GRAPHICS] .

引用

页码：2133 / 2138

页数：6

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