Overexpression of glucocorticoid receptor-β in severe allergic rhinitis

被引：23

作者：

Ishida, Akihiro ^{[1
,2
]}

Ohta, Nobuo ^{[1
]}

Koike, Shuji ^{[1
]}

Aoyagi, Masaru ^{[1
]}

Yamakawa, Mitsunori ^{[2
]}

机构：

[1] Yamagata Univ, Sch Med, Dept Otolaryngol, Yamagata 9909585, Japan

[2] Yamagata Univ, Sch Med, Dept Pathol 1, Yamagata 9909585, Japan

来源：

AURIS NASUS LARYNX | 2010年 / 37卷 / 05期

关键词：

Allergic rhinitis; Glucocorticoid receptor; Resistance; NASAL; EXPRESSION; RESISTANCE; CELLS;

D O I：

10.1016/j.anl.2009.12.002

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Objective: To clarify the role of glucocorticoid receptor-beta in resistance to glucocorticoid therapy for allergic rhinitis, we studied 37 tissue samples from 20 patients with severe allergic rhinitis, and samples from age-matched controls. Methods: Patients were treated with intranasal fluticasone for 6 months and inferior turbinectomy was performed for patients with poor response to glucocorticoid treatment. The expression of glucocorticoid receptor-alpha (GR-alpha), glucocorticoid receptor-beta (GR-beta), and nuclear factor-kappa B (NF-kappa B) in nasal mucosa was studied immunohistochemically. Results: GR-alpha and NF-kappa B were expressed to a similar extent in patients and controls, but GR-beta was expressed significantly more in patients, resulting in an increased GR-beta/GR-alpha ratio. Conclusion: Our findings suggest that GR-beta plays an important role in resistance to glucocorticoid therapy for allergic rhinitis, and its expression might be used as an additional parameter indicating steroid resistance in allergic rhinitis. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：584 / 588

页数：5

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