High transplant-related mortality associated with haematopoietic stem cell transplantation for paediatric therapy-related acute myeloid leukaemia (t-AML). A study on behalf of the United Kingdom Paediatric Blood and Bone Marrow Transplant Group

被引：7

作者：

Gassas, Adam ^{[1
]}

Sivaprakasam, Ponni ^{[1
]}

Cummins, Michelle ^{[1
]}

Breslin, Patricia ^{[1
]}

Patrick, Katharine ^{[2
]}

Slatter, Mary ^{[3
]}

Skinner, Roderick ^{[3
]}

Shenton, Geof ^{[3
]}

Gibson, Brenda ^{[4
]}

Lawson, Sarah ^{[5
]}

Petterson, Toni ^{[6
]}

Potter, Michael ^{[6
]}

James, Beki ^{[7
]}

Hough, Rachael ^{[8
]}

Hiwarkar, Prashant ^{[9
]}

Vora, Ajay ^{[10
]}

Veys, Paul ^{[10
]}

De la Fuente, Josu ^{[11
]}

Wynn, Robert ^{[9
]}

Amrolia, Persis ^{[10
]}

机构：

[1] Royal Hosp Children, Dept Haematol & Oncol, Bristol, Avon, England

[2] Sheffield Childrens Hosp, Dept Haematol & Oncol, Sheffield, S Yorkshire, England

[3] Great North Childrens Hosp, Childrens Haemopoiet Stem Cell Transplant Unit, Newcastle Upon Tyne, Tyne & Wear, England

[4] Royal Hosp Children, Dept Haematol & Oncol, Glasgow, Lanark, Scotland

[5] Birmingham Childrens Hosp, Dept Haematol & Oncol, Birmingham, W Midlands, England

[6] Royal Marsden Hosp, Dept Haematol & Oncol, Sutton, Surrey, England

[7] Leeds Teaching Hosp, Dept Haematol & Oncol, Leeds, W Yorkshire, England

[8] UCL, Dept Haematol & Oncol, London, England

[9] Royal Manchester Childrens Hosp, Dept Haematol & Oncol, Manchester, Lancs, England

[10] Great Ormond St Hosp Sick Children, Dept Haematol & Oncol, London, England

[11] Imperial Coll, St Marys Hosp, Dept Haematol & Oncol, London, England

来源：

BONE MARROW TRANSPLANTATION | 2018年 / 53卷 / 09期

关键词：

MYELODYSPLASTIC SYNDROME; SECONDARY; CHILDREN; FLUDARABINE; BUSULFAN; AML;

D O I：

10.1038/s41409-018-0157-x

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Paediatric therapy-related acute myeloid leukaemia (t-AML) is rare and the outcome is poor. While allogeneic haematopoietic stem cell transplantation (HSCT) is generally the accepted modality of treatment, data regarding salvage chemotherapy, remission induction, conditioning regimens, transplant-related mortality and outcome is scarce. Between 2000 and2016, 36 children with t-AML were treated in seven UK paediatric HSCT centres. The most common salvage protocol for remission induction was FLAG with or without idarubicin and 28 patients were in complete morphological remission prior to BMT. Only 12 patients survived (33%). Transplant-related mortality (TRM) was the leading cause of death.

引用

页码：1165 / 1169

页数：5

共 17 条

[1] Pediatric Therapy-related Myelodysplastic Syndrome/Acute Myeloid Leukemia The MD Anderson Cancer Center Experience
Aguilera, Dolly G.
Vaklavas, Christos
Tsimberidou, Apostolia M.
Wen, Sijin
Medeiros, L. Jeffrey
Corey, Seth J.
[J]. JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 2009, 31 (11) : 803 - 811
[2] Once daily i.v. busulfan and fludarabine (i.v. Bu-Flu) compares favorably with i.v. busulfan and cyclophosphamide (i.v. BuCy2) as pretransplant conditioning therapy in AML/MDS
Andersson, Borje S.
de Lima, Marcos
Thall, Peter F.
Wang, Xuemei
Couriel, Daniel
Korbling, Martin
Roberson, Soonja
Giralt, Sergio
Pierre, Betty
Russell, James A.
Shpall, Elizabeth J.
Jones, Roy B.
Champlin, Richard E.
[J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2008, 14 (06) : 672 - 684
[3] Andersson Borje S, 2009, Curr Opin Oncol, V21 Suppl 1, pS11, DOI 10.1097/01.cco.0000357469.83960.12
[4] Once-daily intravenous busulfan and fludarabine: clinical and pharmacokinetic results of a myeloablative, reduced-toxicity conditioning regimen for allogeneic stem cell transplantation in AML and MDS
de Lima, M
Couriel, D
Thall, PF
Wang, XM
Madden, T
Jones, R
Shpall, EJ
Shahjahan, M
Pierre, B
Giralt, S
Korbling, M
Russell, JA
Champlin, RE
Andersson, BS
[J]. BLOOD, 2004, 104 (03) : 857 - 864
[5] Felice MS, 1998, MED PEDIATR ONCOL, V30, P160, DOI 10.1002/(SICI)1096-911X(199803)30:3<160::AID-MPO6>3.0.CO
[6] 2-F
[7] Bone marrow transplantation for therapy-induced acute myeloid leukemia in children with previous lymphoid malignancies
Hale, GA
Heslop, HE
Bowman, LC
Rochester, RA
Pui, CH
Brenner, MK
Krance, RA
[J]. BONE MARROW TRANSPLANTATION, 1999, 24 (07) : 735 - 739
[8] The impact of therapy-related acute myeloid leukemia (AML) on outcome in 2853 adult patients with newly diagnosed AML
Kayser, Sabine
Doehner, Konstanze
Krauter, Juergen
Koehne, Claus-Henning
Horst, Heinz A.
Held, Gerhard
von Lilienfeld-Toal, Marie
Wilhelm, Sibylla
Kuendgen, Andrea
Goetze, Katharina
Rummel, Mathias
Nachbaur, David
Schlegelberger, Brigitte
Goehring, Gudrun
Spaeth, Daniela
Morlok, Carina
Zucknick, Manuela
Ganser, Arnold
Doehner, Hartmut
Schlenk, Richard F.
[J]. BLOOD, 2011, 117 (07) : 2137 - 2145
[9] Is secondary leukemia an independent poor prognostic factor in acute myeloid leukemia?
Larson, Richard A.
[J]. BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY, 2007, 20 (01) : 29 - 37
[10] Allogeneic transplantation for therapy-related myelodysplastic syndrome and acute myeloid leukemia
Litzow, Mark R.
Tarima, Sergey
Perez, Waleska S.
Bolwell, Brian J.
Cairo, Mitchell S.
Camitta, Bruce M.
Cutler, Corey S.
de Lima, Marcos
DiPersio, John F.
Gale, Robert Peter
Keating, Armand
Lazarus, Hillard M.
Luger, Selina
Marks, David I.
Maziarz, Richard T.
McCarthy, Philip L.
Pasquini, Marcelo C.
Phillips, Gordon L.
Rizzo, J. Douglas
Sierra, Jorge
Tallman, Martin S.
Weisdorf, Daniel J.
[J]. BLOOD, 2010, 115 (09) : 1850 - 1857

← 1 2 →