Two new hepaprotective saponins from Semen celosiae

被引：14
|
作者：
Sun, Zhen-Liang [1 ]
Wang, Ying [2 ]
Guo, Mei-Li [1 ]
Li, Yu-Xian [3 ]
机构：
[1] Second Mil Med Univ, Sch Pharm, Dept Pharmacognosy, Shanghai 200433, Peoples R China
[2] Shenyang Pharmaceut Univ, Coll Chinese Mat Med, Dept Pharmacognosy, Shenyang, Peoples R China
[3] Jilin Agr Sci & Technol Coll, Dept Plant Sci, Changchun, Peoples R China
来源：
FITOTERAPIA | 2010年 / 81卷 / 05期
关键词：
Celosia argentea L; Semen celosiae; Celosin C; Celosin D; Hepatoprotective effect; ANTIMITOTIC BICYCLIC PEPTIDES; TRITERPENOID SAPONINS; CYCLIC PEPTIDE; ARGENTEA; SEEDS; POLYSACCHARIDE; ROOTS;
D O I：
10.1016/j.fitote.2009.11.004
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Two new oleanolic acid saponins, namely celosin C (1) and celosin D (2), were isolated from the ethanol extract of Semen celosiae. Their structures were identified as celosin C (1) and celosin D (2) by spectroscopic and chemical analyses. The hepatoprotective activity of 1 and 2 with oral dose 1.0, 2.0 and 4.0 mg/kg, respectively, were investigated by carbon tetrachloride (CCl4)-induced hepatotoxicity in mice. The results indicate that they have significant hepatoprotective effects (p<0.01). (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码：375 / 380
页数：6
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