Chemoselective debenzylation of N-benzyl tertiary amines with ceric ammonium nitrate

被引：91
作者：
Bull, SD
Davies, SG
Fenton, G
Mulvaney, AW
Prasad, RS
Smith, AD
机构：
[1] Univ Oxford, Dyson Perrins Lab, Oxford OX1 3QY, England
[2] Rhone Poulenc Rorer, Dagenham RM10 7XS, Essex, England
来源：
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 2000年 / 22期
关键词：
D O I：
10.1039/b006852g
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Treatment of a range of N-benzyl tertiary amines with aqueous ceric ammonium nitrate results in N-debenzylation to afford the corresponding secondary amine. Chemoselective mono-N-debenzylation of N-benzyl tertiary amines is shown to occur in the presence of N-benzyl amides, O-benzyl ethers, O-benzyl esters, O-benzyl phenolates and S-benzyl ethers.
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收藏
页码：3765 / 3774
页数：10
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